The present invention relates to a method for diagnosing schizophrenia comprising measuring at least one parameter in a subject, the parameter being selected from the group consisting of (1) a genetic abnormality of glyoxalase I gene, (2) the expression level or activity of glyoxalase I in a biological sample, (3) the amount of a carbonyl-modified protein that is a protein modified with the carbonyl-compound, preferably pentosidine, in a biological sample, and (4) the amount of pyridoxal in a bi...

A combination of an HCV antigen for inducing an antibody having the activity of inhibiting HCV infection and an optimum adjuvant is discovered, so as to provide an effective HCV vaccine composition. The hepatitis C virus vaccine composition comprises: inactivated viral particles obtained by inactivating infectious hepatitis C virus particles prepared from hepatitis C virus genome that contains sequences encoding NS3 protein, NS4A protein, NS4B protein, NS5A protein and NS5B protein derived from ...

Disclosed is an effective HCV vaccine composition, which is developed as a result of the finding of an optimum combination of an HCV antigen capable of inducing an antibody having an inhibitory activity on the infection by an HCV and an adjuvant. Specifically disclosed is a hepatitis C virus vaccine composition which comprises: inactivated virus particles produced by inactivating infectious hepatitis C virus particles that are produced from hepatitis C virus genome containing sequences respectiv...