A solid preparation containing compound (I) wherein the definition of compound (I) is as defined in the description and pioglitazone which is useful as a therapeutic drug for diabetes and the like and superior in the dissolution property chemical stability and dissolution stability is provided. A solid preparation containing the following first and second parts: (1) the first part containing compound (I) or a salt thereof and as the first excipient sugar or sugar alcohol; and (2) the second part...

The present invention provides solid preparation superior in disintegration property and preservation stability. The present invention relates to a solid preparation containing (1) compound (A) or a salt thereof (2) metformin or a salt thereof and (3) crospovidone. It also relates to compound (A) or a salt thereof superior in dissolution property.

A solid preparation sufficiently masking the unpleasant taste of pioglitazone or a salt thereof; a solid preparation sufficiently masking the unpleasant taste of pioglitazone or a salt thereof and having superior properties of superior disintegration property in the oral cavity appropriate preparation strength long-term preservation stability and the like is provided. The present invention provides a solid preparation comprising particles comprising (i) core particles comprising an excipient and...

The present invention provides a pharmaceutical composition comprising a compound represented by the formula (I):wherein each symbol is as defined in the description or a salt thereof in combination with a dipeptidyl peptidase IV inhibitor an insulin preparation a PPAR function modulator an ±-glucosidase inhibitor a biguanide a sulfonylurea mitiglinide or calcium salt hydrate thereof or nateglinide.

A solid preparation containing compound (I) wherein the definition of compound (I) is as defined in the description and pioglitazone which is useful as a therapeutic drug for diabetes and the like and superior in the dissolution property chemical stability and dissolution stability is provided. A solid preparation containing the following first and second parts: (1) the first part containing compound (I) or a salt thereof and as the first excipient sugar or sugar alcohol; and (2) the second part...

A orally disintegrating tablet is obtained by tableting fine granules showing controlled release of lansoprazole and an additive which is capable of suppressing breakage of the fine granules during tableting and can control the release of lansoprazole for a long time and can maintain a therapeutically effective concentration for a prolonged time and shows superior disintegration property in the oral cavity.

The present invention relates to a production method of a crystal of (R)-lansoprazole or (S)-lansoprazole which includes crystallization at a temperature of about 0°C to about 35°C from a C1-4 alkyl acetate solution containing (R)-lansoprazole or (S)-lansoprazole at a concentration of about 0.1 g/mL to about 0.5 g/mL and the like. According to the production method of the present invention a crystal of (R)-lansoprazole or (S)-lansoprazole superior in preservation stability can be produced effici...

The present invention provides a solid preparation containing compound (I) [compound (I) is as defined in the specification] or a salt thereof and metformin hydrochloride which is useful as a therapeutic drug for diabetes and the like and superior in the preservation stability. A solid preparation having a first part and a second part:a first part: a part containing compound (I) or a salt thereof and substantially free of metformin hydrochloride a second part: a part containing metformin hydroch...

A orally disintegrating tablet is obtained by tableting fine granules showing controlled release of lansoprazole and an additive which is capable of suppressing breakage of the fine granules during tableting and can control the release of lansoprazole for a long time and can maintain a therapeutically effective concentration for a prolonged time and shows superior disintegration property in the oral cavity.