Disclosed are methods of treating a tumor in a subject that include a step of administering to the subject a therapeutic composition that comprises: (a) mycophenolic acid an analogue thereof or a derivative thereof; and (b) at least one antineoplastic agent. The antineoplastic agent may include at least one of 5-fluouracil (5-FU) paclitaxel oxaliplatin doxorubicin etoposide irinotecan bleomycin imiquimod 13-cis-retinoic acid and combinations thereof. The mycophenolic acid may not be derivatized....

The present invention relates to a salt of a carboxylic acid with a diamine such as 22'-(ethylenedioxy)diethyl amine 33'-(ethylenedioxy)dipropyl amine and 22'-oxybis(ethylamine) and a method of preparing such salts. Preferably the carboxylic acid is a fermentation product such as clavulanic acid mycophenolic acid or pravastatin.

The present invention relates to a new and economically attractive process for the production of mycophenolate mofetil in a high degree of pharmaceutically acceptable purity which comprises the reaction of a reactive derivative of mycophenolic acid with 4-(2-hydroxyethyl)morpholine under acidic reaction conditions and the subsequent extraction of the pure mycophenolate mofetil through salt formation and release of the free base. A further aspect of the invention relates to the purification of my...

A PROCESS FOR MODIFYING THE CRYSTAL HABIT OF ACICULAR DRUG SUBSTANCES CRYSTALS OBTAINED BY SUCH A PROCESS AND PARTICULAR CRYSTAL FORMS OR MODIFICATIONS OF MYCOPHENOLIC ACID OR MYCOPHENOLATE SODIUM ARE PROVIDED AS WELL AS PHARMACEUTICAL COMPOSITIONS COMPRISING THE CRYSTALS METHOD OF TREATMENT AND USES THEREOF.

The present invention relates to the use of mycophenolic acid [also referred to synonymously as "MPA" or according to IUPAC nomenclature also as "(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-l3-dihydroisobenzofliran-5-yl)-4-methyl-hex-4-enoic acid"] or its pharmacologically effective and physiologically compatible salts or esters for the curative and/or prophylactic treatment of vascular diseases.

In some embodiments the present invention provides methods of treating a tumor in a subject. In some embodiments the methods may include a step of administering to the subject a therapeutic composition that comprises: (a) mycophenolic acid an analogue thereof or a derivative thereof; and (b) at least one anti-neoplastic agent. In some embodiments the anti¬ neoplastic agent may include at least one of 5-fluouracil (5-FU) paclitaxel oxaliplatin doxorubicin etoposide irinotecan bleomycin imiquimod ...

Disclosed in the present invention is a mycophenolic acid derivative shown by the following general formula (V) and the pharmaceutically acceptable salts thereof wherein L.sub.1 is -O-R.sub.2 -QCOOR.sub.2 or -QCONR.sub.2R.sub.3 Q is C.sub.1~C.sub.10. Alkylidene or C.sub.1~C.sub.6alkenylene; L.sub.2 is -O-R.sub.1 or -O.sup.-·M.sup.+. Also provided in the present invention is a pharmaceutical composition containing the mycophenolic acid derivative and pharmaceutically acceptable salts thereof and ...