Disclosed are benztropine analogs having the formula (I) in which Ar is a C6-C20 monocyclic aryl group or a C10-C20>bicyclic aryl group or a heteroaryl, heterocyclic, or arylheterocyclic group having 2 to 12 carbon atoms and one or more heteroatoms selected from the group consisting of N, O, S, P, and any combination thereof

Three anticholinergic agents are used to treat nicotine dependency and reduce tobacco use. A method is described for treatment of nicotine dependency and cessation or reduction of tobacco use in humans which combines pharmacotherapy designed to ameliorate the initial withdrawal symptoms followed by behavioral modification intended to minimize the relapse rate. Pharmacotherapy consists of the use of anticholinergic agents, which facilitate a smooth withdrawal from nicotine. A composition is descr...

A method is described for treatment of nicotine dependency and cessation or reduction of tobacco use in humans which combines pharmacotherapy designed to ameliorate the initial withdrawal symptoms followed by behavioral modification intended to minimize the relapse rate. Pharmacotherapy consists of the use of anticholinergic agents, which facilitate a smooth withdrawal from nicotine. A composition is described comprising scopolamine, glycopyrrolate and benztropine which is injected parenterally....

Disclosed are benztropine analogs having the formula (I) in which Ar is a C6-C20 monocyclic aryl group or a C10-C20 bicyclic aryl group or a heteroaryl, heterocyclic, or arylheterocyclic group having 2 to 12 carbon atoms and one or more heteroatoms selected from the group consisting of N, O, S, P, and any combination thereof

A composition comprising a polypeptide and benzatropine mesylate covalently attached to the polypeptide.Also provided is a method for delivery of benzatropine mesylate to a patient comprising administering to the patient a composition comprising a polypeptide and benzatropine mesylate covalently attached to the polypeptide.Also provided is a method for protecting benzatropine mesylate from degradation comprising covalently attaching it to a polypeptide.Also provided is a method for controlling r...

1. A pharmaceutical tablet composition of durable action, which comprises: a rapidly precipitating drug in an amount from about 5 to about 60%, and at least one member selected from the group consisting of a binder in an amount of from about 2 to about 25% and a superdisintegrant in an amount from about 6 to about 40% where the rapidly precipitating drug is a relatively soluble or high soluble salt form of a poorly soluble drug, which is free base or free acid. 2. A composition according to clai...

The present invention provides a family of tropane analogs. More particularly, the present invention provides a family of 4' and 4',4''-substituted-3 alpha -(diphenylmethoxy)tropane analogs having the formula (I) in which R is a functional group including, but not limited to, hydrogen, alkyl, alkoxy, arylalkyl, aryloxyalkyl, cinnamyl and acyl