Disclosed are novel isoflavone derivatives having the structure of Formula I: which are ALDH-2 inhibitors useful for treating a patient in need thereof for dependence upon drugs of addiction for example addiction to dopamine-producing agent such as cocaine morphine amphetamines nicotine and alcohol.

A method of treating an animal suffering from a painful condition or disease comprising administering to the animal an effective amount of a compound of Formula (I) or pharmaceutically acceptable salt thereof, wherein, the animal is livestock or a companion animal.