A combination of two drugs from different and unrelated categories provides effective and long-lasting relief from neuropathic pain and other chronic or intractable pain. Both drugs can be taken in a painless non-invasive manner such as by means of pills or skin patches. One drug is an α2 adrenergic agonist exemplified by clonidine. These agents reduce blood pressure and have sedative-hypnotic effects; those are unwanted side effects in a chronic daily treatment for pain. The other drug is an NM...

This invention discloses that a combination of two drugs from two different and unrelated categories provides effective and long-lasting relief from neuropathic pain. Both drugs can be taken orally in a convenient painless non-invasive manner that does not require injections. One drug is an aryl-cyclo-alkanolamine (ACAA) which has antagonist (receptor-blocking) activity at the NMDA subclass of glutamate receptors; such drugs include procyclidine biperiden and trihexyphenidyl. The other drug is a...

This invention discloses that a combination of two drugs, from two different and unrelated categories, provides effective and long-lasting relief from neuropathic pain. Both drugs can be taken orally, in a convenient, painless, non-invasive manner that does not require injections. One drug is an aryl-cyclo-alkanolamine (ACAA) which has antagonist (receptor-blocking) activity at the NMDA subclass of glutamate receptors

A method for treating urinary incontinence such as incontinence resulting from bladder detrusor muscle instability using enantiomerically enriched (R)-procyclidine.The method comprises administering a therapeutically effective amount of enantiomerically enriched (R)-procyclidine or a pharmaceutically acceptable salt thereof substantially free of the (S)-procyclidine enantiomer.Pharmaceutical compositions for the treatment of urinary incontinence comprising enantiomerically enriched (R)-procyclid...

A method for treating urinary incontinence such as incontinence resulting from bladder detrusor muscle instability using enantiomerically enriched (S)-procyclidine.The method comprises administering a therapeutically effective amount of enantiomerically enriched (S)-procyclidine or a pharmaceutically acceptable salt thereof substantially free of the (R)-procyclidine enantiomer.Pharmaceutical compositions for the treatment of urinary incontinence comprising enantiomerically enriched (S)-procyclid...

A combination of two drugs, from different and unrelated categories, provides effective and long-lasting relief from neuropathic pain and other chronic or intractable pain. Both drugs can be taken in a painless non-invasive manner, such as by means of pills or skin patches. One drug is an alpha 2 adrenergic agonist, exemplified by clonidine. These agents reduce blood pressure and have sedative-hypnotic effects

A method for treating urinary incontinence, such as incontinence resulting from bladder detrusor muscle instability, using enantiomerically enriched (S)-procyclidine. The method comprises administering a therapeutically effective amount of enantiomerically enriched (S)-procyclidine, or a pharmaceutically acceptable salt thereof, substantially free of the (R)-procyclidine enantiomer. Pharmaceutical compositions for the treatment of urinary incontinence comprising enantiomerically enriched (S)-pro...

A method for treating urinary incontinence such as incontinence resulting from bladder detrusor muscle instability using enantiomerically enriched (S)-procyclidine. The method comprises administering a therapeutically effective amount of enantiomerically enriched (S)-procyclidine or a pharmaceutically acceptable salt thereof substantially free of the (R)-procyclidine enantiomer. Pharmaceutical compositions for the treatment of urinary incontinence comprising enantiomerically enriched (S)-procycl...