One embodiment of an aspect of the present invention is a method for lessening the symptoms of depression anxiety and post-traumatic stress disorder comprising the step of administering a therapeutically effective quantity of a cholinergic M1 receptor antagonist and a therapeutically effective quantity of one or more cholinomimetic agents to lessen the symptoms of depression anxiety and post-traumatic stress disorder. Typically the cholinergic M1 receptor antagonist is selected from the group co...

The invention relates to a method for the production of biperiden by reacting an exo/endo mixture of 1-(bicyclo[2.2.1.]hept-5-en-2-yl) 3-piperidino-1-propanone with a phenyl magnesium compound wherein the exo/endo ratio of 1-(bicylo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone is at least 4.5:1.(From US6835839 B2)

The invention relates to a method for the production of biperiden by reacting an exo/endo mixture of 1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone with a phenyl magnesium compound to form an isomer mixture of 1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-piperidino-1-propanol whereby biperiden is obtained therefrom by conversion of said mixture into corresponding hydrochloride isolation of said hydrochloride reconversion to the free base and crystallization of said biperiden.(From US...

The invention relates to a method for producing biperiden which is characterized in that an exo/endo mixture of 1-(bicyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone is reacted with an isomer ratio of the exo form to the endo form of at least 2.5:1 with diphenyl magnesium an isomer mixture containing biperiden is obtained therefrom and biperiden is produced therefrom.(From US7034158 B2)