A pharmaceutical composition for treating colitis induced by pernicious enteric bacteria is provided to inhibit growth of pernicious enteric bacteria and minimize side effects on the whole body by using chelates of tetracycline compounds which are rarely absorbed in the intestines and used as food of pernicious enteric bacteria due to their large molecular size. A pharmaceutical composition for treating colitis induced by pernicious enteric bacteria comprises tetracycline compounds and compounds...

1. A method of preparing a 7-, 8-, 9- or 10-substituted tetracycline compound, combining a reactive tetracycline-based precursor compound and a reactive organic substituent precursor in the presence of a transition metal catalyst under conditions such that a tetracycline compound substituted with said organic substituent is formed. 2. The method of claim 1, wherein said transition metal catalyst comprises an organopalladium catalyst. 3. The method of claim 2, wherein said organopalladium catalys...

1. A method of preparing a 7- 8- 9- or 10-substituted tetracycline compound combining a reactive tetracycline-based precursor compound and a reactive organic substituent precursor in the presence of a transition metal catalyst under conditions such that a tetracycline compound substituted with said organic substituent is formed. 2. The method of claim 1 wherein said transition metal catalyst comprises an organopalladium catalyst. 3. The method of claim 2 wherein said organopalladium catalyst com...