Provided in the present invention are a cocrystal of piperacillin sodium and sulbactam sodium and a preparation method therefor, as well as pharmaceutical compositions containing the same and uses thereof in treating infections caused by drug-resistant bacteria, such as a "super bacterium" producing NDM-1 and the like. The cocrystal of piperacillin sodium and sulbactam sodium contains diffraction angles of 14.24 DEG , 16.58 DEG , 16.79 DEG , 17.77 DEG , 19.20 DEG , 20.21 DEG , 20.39 DEG , 23.06 ...

Substituted bicyclic beta-lactams of Formula I:are ²-lactamase inhibitors wherein a X R 1 and R 2 are defined herein. The compounds and pharmaceutically acceptable salts thereof are useful in the treatment of bacterial infections in combination with ²-lactam antibiotics. In particular the compounds can be employed with a ²-lactam antibiotics (e.g. imipenem piperacillin or ceftazidime) against microorganisms resistant to ²-lactam antibiotics due to the presence of the ²-lactamases.

Substituted bicyclic beta-lactams of Formula I:are ²-lactamase inhibitors wherein a X R 1 and R 2 are defined herein. The compounds and pharmaceutically acceptable salts thereof are useful in the treatment of bacterial infections in combination with ²-lactam antibiotics. In particular the compounds can be employed with a ²-lactam antibiotics (e.g. imipenem piperacillin or ceftazidime) against microorganisms resistant to ²-lactam antibiotics due to the presence of the ²-lactamases.

Substituted bicyclic beta-lactams of Formula I:are ²-lactamase inhibitors wherein a X R 1 and R 2 are defined herein. The compounds and pharmaceutically acceptable salts thereof are useful in the treatment of bacterial infections in combination with ²-lactam antibiotics. In particular the compounds can be employed with a ²-lactam antibiotics (e.g. imipenem piperacillin or ceftazidime) against microorganisms resistant to ²-lactam antibiotics due to the presence of the ²-lactamases.

Substituted bicyclic beta-lactams of Formula I: are -lactamase inhibitors, wherein a , X, R 1 and R 2 are defined herein. The compounds and pharmaceutically acceptable salts thereof are useful in the treatment of bacterial infections in combination with -lactam antibiotics. In particular, the compounds can be employed with a -lactam antibiotics (e.g., imipenem, piperacillin, or ceftazidime) against microorganisms resistant to -lactam antibiotics due to the presence of the -lactamases.

Substituted bicyclic beta-lactams of Formula I: are beta-lactamase inhibitors wherein a X R1 and R2 are defined herein. The compounds and pharmaceutically acceptable salts thereof are useful in the treatment of bacterial infections in combination with beta-lactam antibiotics. In particular the compounds can be employed with a beta-lactam antibiotics (e.g. imipenem piperacillin or ceftazidime) against microorganisms resistant to beta-lactam antibiotics due to the presence of the beta-lactamases.