A method and a composition for treatment of pulmonary bacterial infections caused by gram-negative bacteria suitable for treatment of infection caused by Escherichia coli Klebsiella pneumoniae Klebsiella oxytoca Pseudomonas aeruginosa Haemophilus influenzae Proteus mirabilis Enterobacter species Serratia marcescens as well as those caused by Burkholderia cepacia Stenotrophomonas maltophilia Alcaligenes xylosoxidans and multidrug resistant Pseudomonas aeruginosa using a concentrated formulation o...

A method and a composition for treatment of pulmonary bacterial infections caused by gram-negative bacteria suitable for treatment of infection caused by Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species, Serratia marcescens as well as those caused by Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans, and multidrug resistant Pseudomonas aeruginosa, using a concentrated fo...

±-Aztreonam lysinate is able to be administered via inhalation. It is useful in the treatment of pulmonary bacterial infections particularly gram-negative bacterial infections.

It discloses a process for refining Aztreonam, comprising the steps of 1) treating Aztreonam material with an alkali metal alkoxylate or an alkali earth metal alkoxylate under heating in the presence of a suitable solvent or a mixture of solvents, followed by adjusting the pH value with a suitable acid and cooling down to precipitate Aztreonam, which provides a primary purified Aztreonam

It discloses a process for refining Aztreonam comprising the steps of 1) treating Aztreonam material with an alkali metal alkoxylate or an alkali earth metal alkoxylate under heating in the presence of a suitable solvent or a mixture of solvents followed by adjusting the pH value with a suitable acid and cooling down to precipitate Aztreonam which provides a primary purified Aztreonam; 2) adsorbing Aztreonam with strongly basic ion exchange resin followed by eluting the resin and collecting the ...

±-Aztreonam lysinate is able to be administered via inhalation. It is useful in the treatment of pulmonary bacterial infections particularly gram-negative bacterial infections.

Aztreonam lysinate is able to be administered via inhalation. It is useful in the treatment of pulmonary bacterial infections particularly gram-negative bacterial infections. Preparation of aztreonam lysinate using ��-aztreonam provides an advantageous manufacturing process and a product which has high purity and stability.