Substituted bicyclic beta-lactams of Formula I:are ²-lactamase inhibitors wherein a X R 1 and R 2 are defined herein. The compounds and pharmaceutically acceptable salts thereof are useful in the treatment of bacterial infections in combination with ²-lactam antibiotics. In particular the compounds can be employed with a ²-lactam antibiotics (e.g. imipenem piperacillin or ceftazidime) against microorganisms resistant to ²-lactam antibiotics due to the presence of the ²-lactamases.

Substituted bicyclic beta-lactams of Formula I:are ²-lactamase inhibitors wherein a X R 1 and R 2 are defined herein. The compounds and pharmaceutically acceptable salts thereof are useful in the treatment of bacterial infections in combination with ²-lactam antibiotics. In particular the compounds can be employed with a ²-lactam antibiotics (e.g. imipenem piperacillin or ceftazidime) against microorganisms resistant to ²-lactam antibiotics due to the presence of the ²-lactamases.

Substituted bicyclic beta-lactams of Formula I:are ²-lactamase inhibitors wherein a X R 1 and R 2 are defined herein. The compounds and pharmaceutically acceptable salts thereof are useful in the treatment of bacterial infections in combination with ²-lactam antibiotics. In particular the compounds can be employed with a ²-lactam antibiotics (e.g. imipenem piperacillin or ceftazidime) against microorganisms resistant to ²-lactam antibiotics due to the presence of the ²-lactamases.

Substituted bicyclic beta-lactams of Formula I: are beta-lactamase inhibitors wherein a X R1 and R2 are defined herein. The compounds and pharmaceutically acceptable salts thereof are useful in the treatment of bacterial infections in combination with beta-lactam antibiotics. In particular the compounds can be employed with a beta-lactam antibiotics (e.g. imipenem piperacillin or ceftazidime) against microorganisms resistant to beta-lactam antibiotics due to the presence of the beta-lactamases.

Substituted bicyclic beta-lactams of Formula I: are beta-lactamase inhibitors, wherein a, X, R1 and R2 are defined herein. The compounds and pharmaceutically acceptable salts thereof are useful in the treatment of bacterial infections in combination with beta-lactam antibiotics. In particular, the compounds can be employed with a beta-lactam antibiotics (e.g., imipenem, piperacillin, or ceftazidime) against microorganisms resistant to beta-lactam antibiotics due to the presence of the beta-lacta...

Substituted bicyclic beta-lactams of Formula I: (I) are beta-lactamase inhibitors wherein a X R1 and R2 are defined herein. The compounds and pharmaceutically acceptable salts thereof are useful in the treatment of bacterial infections in combination with beta-lactam antibiotics. In particular the compounds can be employed with a beta-lactam antibiotics (e.g. imipenem piperacillin or ceftazidime) against microorganisms resistant to beta-lactam antibiotics due to the presence of the beta-lactamas...