The present invention relates to a novel pharmaceutical composition of Linezolid. The present invention relates to a novel pharmaceutical composition comprising Linezolid Form III along with pharmaceutically acceptable excipients and a process to prepare the said composition. The present invention relates to an oral dosage forms for the treatment of severe infections caused by Gram-positive bacteria.

A method for preparing the linezolid (compound 1) which comprises the steps of: (1) carrying out the debenzyl reaction of compound 4 in solvent to obtain the compound 5 or its acetic acid salt; (2) carrying out the acetylation reaction in the amino of the compound 5 or its acetic acid salt obtained in step (1) in solvent to obtain the compound 1. The intermediates to prepare the compound 1 and the acetic acid salt of compound 5. The present preparation method is easy to obtain the chiral materia...

The present invention relates to stable pharmaceutical compositions comprising linezolid crystalline Form III with one or more pharmaceutically acceptable excipients wherein the composition retains linezolid in its original crystalline form.

The present invention relates to a process for making linezolid comprising reacting in an aqueous medium a water soluble acid addition salt of the compound of formula (II)with acetyl halide or acetic acid anhydride in the presence of a base.

Provided are a linezolid intermediate and the preparation method thereof and a method for synthesizing linezolid. The structure of the intermediate is shown as formula F2 wherein the compound is prepared by a condensation reaction of (S)-N-(3-chloro-2-hydroxy-1-propyl) acetamide and the compound shown in formula F4. In the preparation methods of the compound shown in formula F2 and linezolid the reaction system is mild side reactions are few and the product yield is high.