Disclosed is a chewable antibiotic veterinary formulation comprising: an antibiotic, selected from group consisting of beta lactams, semisynthetic penicillins, bacitracin, cephalosporins, quinolones, fluorinated quinolones, polymyxin, tetracyclines, chloramphenicol, aminoglycosides, nalidixic acid, rifamycins, sulfonamides, amikacin, aminosalicyclic acid, amoxicillin, amoxicillin and clavulanate potassium, ampicillin, bacampicillin, bacitracin, capreomycin, carbenicillin, carbenicillin indanyl s...

The present invention relates to a process for preparing a substituted tetracycline compound comprising contacting a reactive tetracycline chemical complex comprising a reactive tetracycline-based precursor compound having at least one reactive site selected from position 7 9 or 13 and a transition metal catalyst forming a reactive chemical intermediate with a reactive organic substituent precursor or combining a reactive tetracycline-based precursor compound having at least one reactive site se...

1. A method of preparing a 7- 8- 9- or 10-substituted tetracycline compound combining a reactive tetracycline-based precursor compound and a reactive organic substituent precursor in the presence of a transition metal catalyst under conditions such that a tetracycline compound substituted with said organic substituent is formed. 2. The method of claim 1 wherein said transition metal catalyst comprises an organopalladium catalyst. 3. The method of claim 2 wherein said organopalladium catalyst com...

A method of lowering intraocular pressure in the eye of a human or an animal, the method involving administering to the eye, an agent comprising an amount of tetracycline or a tetracycline related compound, such as demeclocycline, sufficient to achieve a significant lowering of intraocular pressure.

A method of lowering intraocular pressure in the eye of a human or an animal the method involving administering to the eye an agent comprising an amount of tetracycline or a tetracycline related compound such as demeclocycline sufficient to achieve a significant lowering of intraocular pressure.