ABSTRACT - 593892 The disclosure relates to compounds represented by the structural formula depicted herein, which can be derived from polymyxin, including, peptides such as polymyxin B and the related colistin (polymyxin E). These compounds have antibacterial properties against a diverse range of gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin B. Also provided are antibacterial pharmaceutical compositions containing these compounds, as well as methods for pr...

For administration via intravenous route at higher dosages with greater clinical effectiveness reaching higher tissue concentrations and without determining side effects at a renal level colistin a known bactericide against Gram-negative bacteria is chemiadsorbed on a substrate of liposomes. The liposome composition containing colistin that is obtained can be administered via intravenous route or else in the form of syrup for oral use as intestinal decontaminant whilst in topical formulations su...