The invention relates to medicine specifically to dentistry and concerns medicinal agents for the prophylaxis and treatment of infectious and inflammatory periodontal diseases particularly medicinal agents for the prophylaxis and treatment of periodontosis. Essence of the invention: A pharmaceutical composition in the form of a gel for the prophylaxis and treatment of periodontal diseases containing metronidazole benzoate and chlorhexidine gluconate as the active agent carbomer and hydroxypropyl...

FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to pharmaceutics and represents a combined drug preparation for the local treatment of periodontics, including a complex of metronidazole and chlorhexidine in a combination with sodium fusidine, sweetening agents and a pharmaceutically acceptable gel base in the following proportions, g: sodium fusidine 1.8-2.2

The combination of any two of a polyol a polyol ether and a low carbon organic alcohol provides a synergistic effect on the solubility of azole compounds such as metronidazole in aqueous fluid.

The methods described herein provide treatment of rosacea using topical formulations of dapsone. The methods also provide treatment of rosacea with topical dapsone in combination with other active agents, including metronidazole. The methods avoid negative hematologic side effects, including hemolysis and hemolytic anemia, that are associated with oral administration of dapsone.

The methods described herein provide treatment of rosacea using topical formulations of dapsone. The methods also provide treatment of rosacea with topical dapsone in combination with other active agents including metronidazole. The methods avoid negative hematologic side effects including hemolysis and hemolytic anemia that are associated with oral administration of dapsone.