1. Penicillin reverses resistance of mycobacterium to INH. 2. Penicillin as claimed in claim 1 can be a broad spectrum penicillin or a narrow spectrum penicillin. 3. Penicillin as claimed in claim 1 and 2 can be any single penicillin or combination of more than one penicillin. 4. Penicillin as claimed in claim 1 to 3 can have activity against beta-lactamase producing organism. 5. Penicillin as claimed in claim 1 to 3 can have activity against penicillinase producing organism. 6. Penicillin as cl...

1. The method of treating drug-resistant mycobacterial infection in an animal comprising administration to the said animal Penicillin and isoniazid (INH). 2. The method of claim 1 wherein penicillin is administered simultaneously with INH. 3. The method as claimed in claim 1 wherein penicillin and INH are administered sequentially. 4. The method as claimed in claim 1 to 3 wherein penicillin can be a broad spectrum penicillin or a narrow spectrum penicillin. 5. The method as claimed in claim 1 to...

PURPOSE: To provide a new cephem derivative stably producible in high yield and useful as a production intermediate for a cephem-type antibiotic substance especially cefaclor.CONSTITUTION: The compound of formula I (R is ester residue; X is CH(sub 2) or O) i.e. 2-[3-(22-dimethyl-3-nitroso-4-phenyl-5-oxo-1-imidazolidinyl)-4-(p- toluenesulfonylthio)-2-oxoazetidin-1-yl]3-methylene-butyric acid ester (X=CH(sub 2)) and -3-oxo-butyric acid ester (X=O). The compound of formula I wherein X is CH(sub 2) ...

PURPOSE: To obtain the subject compound useful as an antibiotic substance in high yield by treating a specific compound with an acid.CONSTITUTION: The objective compound of formula II can be produced by treating a compound of formula I [R(sub 1) and R(sub 2) are H lower alkyl (substituted) phenyl or together form lower alkylene; R(sub 3) is nitroso benzyl benzyloxycarbonyl p-nitrobenzyloxycarbonyl or tert-butyloxycarbonyl; R(sub 4) is H or carboxy-protecting group; X is halogen] with an acid aft...

Bis-esters of methanediol wherein one hydroxy group of the methanediol is esterified with the carboxy group of hetacillin (or of the p-hydroxy analog of hetacillin) and the other hydroxy group of the methanediol is esterified with penicillanic acid 11-dioxide. These orally effective compounds have a particularly broad spectrum of antibacterial activity in mammals and have an unusually long serum half-life.