The present invention relates to amphiphilic aminoglycoside (AG) derivatives especially derivatives of tobramycin kanamycin A and paromomycin comprising hydrophobic side chains linked to the AG moiety by various linkers. These novel derivatives are useful as broad spectrum antibacterial agents targeting bacterial cell membranes while having minimal toxicity due to non-selective targeting of eukaryotic cell membranes. The present invention further relates to methods for preparing the novel deriva...

FIELD: biotechnologies.SUBSTANCE: recombinant hybrid inhibitor of angiogenesis represents a protein shown in dwg. 1. This protein includes amino acid sequence of plasminogen of a human being from amino acid 82 to 341 and sequence Cys-Asp-Cys-Arg-Gly-Asp-Cys-Phe-Cys which are covalently connected to each other. An inhibitor production method involves expression of its gene in cells of E. coli producer strain which are transfected with recombinant plasmid DNA pBSRK13 with a physical map presented ...