Disclosed herein is a method of taste masking a fluoroquinolone preferably one selected from the group of ciprofloxacin gatifloxacin gemifloxacin norfloxacin moxifloxacin marbofloxacin orbifloxacin sparfloxacin tosufloxacin trovafloxacin pefloxacin lomefloxacin clinafloxacin prulifloxacin sarafloxacin sitafloxacin and pazufloxacin; the method comprising combining the fluoroquinolone with an amount of a divalent or trivalent cation sufficient to mask the taste of the fluoroquinolone. Suitable cat...

The present invention relates to an aqueous pharmaceutical composition comprising a) 0.01 to 30 percent by weight of a quinolone compound being selected from the group consisting of orbifloxacin grepafloxacin nalidixic acid sparfloxacin or trovafloxacin mesylate b) 0.2 to 20 percent by weight of an ion exchange resin prepared from a porous copolymer of methacrylic acid crosslinked with divinylbenzene and c) pharmaceutically acceptable excipients to equal 100 percent.

The present invention relates to a new process for preparing beta-ketoester compound of the following formula (1) which is a useful intermediate for the synthesis of such quinoline antibiotics as Ciprofloxacin Levofloxacin Gemifloxacin Trovafloxacin etc.The quinoline antibiotics obtained from the above compound of formula (1) show potent antibacterial activity and so are advantageously used as a therapeutic agent for bacterial infections of humans or animals.(From US6987199 B2)

TROVAFLOXACIN ACID SALTS ARE PREPARED VIA THE HYDROLYSIS OF IMINE INTERMEDIATES USING MINERAL ACID INCLUDING BUT NOT LIMITED TO METHANESULFONIC ACID ETHANESULFONIC ACID BENZENESULFONIC ACID NITRIC ACID SULFURIC ACID PHOSPHORIC ACID HYDROCAHLORIC ACID HYDROBROMIC ACID TARTARIC ACID CITRIC ACID ACETIC ACIDAND MALEIC ACID. TROVAFLOXACIN ACID SALTS ARE USEFUL AS ANTIBIOTIC AGENTS.

The present invention relates to a new process for preparing beta-ketoester compound of the following formula (1) which is a useful intermediate for the synthesis of such quinoline antibiotics as Ciprofloxacin Levofloxacin Gemifloxacin Trovafloxacin etc. The quinoline antibiotics obtained from the above compound of formula (1) show potent antibacterial activity and so are advantageously used as a therapeutic agent for bacterial infections of humans or animals.

The present invention relates to a new process for preparing beta-ketoester compound of the following formula (1) which is a useful intermediate for the synthesis of such quinoline antibiotics as Ciprofloxacin Levofloxacin Gemifloxacin Trovafloxacin etc.The quinoline antibiotics obtained from the above compound of formula (1) show potent antibacterial activity and so are advantageously used as a therapeutic agent for bacterial infections of humans or animals.(From US6987199 B2)