The present invention relates to a process for preparing acid salts of Gemifloxacin a quinolone type antibiotic agent having potent antimicrobial activity. The process according to the present invention can provide advantages such as simplicity of process improvement of productivity and improvement of yield and the like by reducing conventional three-step process to two-step process.

Disclosed herein is a method of taste masking a fluoroquinolone preferably one selected from the group of ciprofloxacin gatifloxacin gemifloxacin norfloxacin moxifloxacin marbofloxacin orbifloxacin sparfloxacin tosufloxacin trovafloxacin pefloxacin lomefloxacin clinafloxacin prulifloxacin sarafloxacin sitafloxacin and pazufloxacin; the method comprising combining the fluoroquinolone with an amount of a divalent or trivalent cation sufficient to mask the taste of the fluoroquinolone. Suitable cat...

The invention encompasses soluble effervescent tablet sachet and dry syrup formulations and manufacturing methods of gemifloxacin or pharmaceutically acceptable salt.

The invention encompasses wet granulation with an organic solvent direct compression dry granulation manufacturing methods and pharmaceutical formulations of anhydrous gemifloxacin mesylate.

The invention relates to the use of a gemifloxacin compound for the treatment of neurodegenerative diseases mild cognitive impairment cognitive deficiencies dementia diseases associated with ageing and pathological processes associated with age and progeria and in particular Alzheimer's disease owing to the discovery of novel properties intrinsic to said compound.

The present invention provides a novel process for the preparation of gemifloxacin and its pharmaceutically acceptable acid addition salts in high yield. The present invention also relates to novel polymorphs of gemifloxacin free base and its hydrates to the processes for their preparation and to pharmaceutical compositions comprising them. The present invention also relates to infusion solutions of gemifloxacin and to processes for their preparation. Thus 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1...

The present invention provides a novel process for the preparation of gemifloxacin and its pharmaceutically acceptable acid addition salts in high yield. The present invention also relates to novel polymorphs of gemifloxacin free base and its hydrates to the processes for their preparation and to pharmaceutical compositions comprising them. The present invention also relates to infusion solutions of gemifloxacin and to processes for their preparation. Thus, 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-...