The present invention relates to treatment of animals with fluoroquinolones. More specifically the present invention relates to the use of fluoroqunolones in a single high dose to replace multiple lower doses. lt;SDOCL LA=ENgt; -6- CLAIMS 1. Use of a fluoroquinolone or a salt or ester thereof in the manufacture of a medicament for treating bovine respiratory disease wherein said medicament is a single high dose medicament and comprises the fluoroquinolone or a salt or ester thereof in a dose of ...