The present application provides methods and compositions for combination therapy with antiviral compounds for the treatment of poxvirus infections such as orthopox virus infections. In one embodiment a method of treatment of a poxvirus infection is provided that comprises administering to a host in need thereof cidofovir cyclic cidofovir or a salt ester or prodrug thereof in combination or alternation with at least a second anti-poxvirus agent. The second anti-poxvirus agent is for example a bi...

The present invention relates to lyophilized compositions comprising cidofovir hydroxypropyl methylcellulose (HPMC) or hydroxyethylcellulose (HEC) and optionally a plasticizer. In particular the present invention relates to such compositions which form a sheet-shaped porous solid matrix. The invention also relates to methods for producing such compositions. The invention further relates to such compositions for use in treating human papillomavirus (HPV) infections and HPV-associated malignancies...

This disclosure provides anti-human cytomegalovirus antibodies and methods of treatment prophylaxis detection and diagnosis using the same. In another aspect the disclosure features therapeutic prophylactic and/or diagnostic compositions for human cytomegalovirus infection or for a human cytomegalovirus-related disease that include a binding agent (e.g. antibody) or polynucleotide disclosed herein. In some embodiments the composition is formulated for ocular or topical administration. The compos...

The present application provides methods and compositions for combination therapy with antiviral compounds for the treatment of poxvirus infections such as orthopox virus infections. In one embodiment a method of treatment of a poxvirus infection is provided that comprises administering to a host in need thereof cidofovir cyclic cidofovir or a salt ester or prodrug thereof in combination or alternation with at least a second anti-poxvirus agent. The second anti-poxvirus agent is for example a bi...

FIELD: medicine pharmaceutics.SUBSTANCE: claimed are: application of silibinin component of general formula(I) for obtaining medication for parenteral introduction for trweatment of viral hepatitis with medication optionally containing cyclodextrin and/or phospholipid and set of similar purpose which includes said silibinin component and other medication representing one or several pharmaceutical agents from: arginine glutamate silymarin citiolone epodemiol ornithine oxoglurate tidiacic arginine...

The present invention relates to lyophilized compositions comprising cidofovir hydroxypropyl methylcellulose (HPMC) or hydroxyethylcellulose (HEC) and optionally a plasticizer. In particular the present invention relates to such compositions which form a sheet-shaped porous solid matrix. The invention also relates to methods for producing such compositions. The invention further relates to such compositions for use in treating human papillomavirus (HPV) infections and HPV-associated malignancies...

The present invention relates to lyophilized compositions comprising cidofovir hydroxypropyl methylcellulose (HPMC) or hydroxyethylcellulose (HEC) and optionally a plasticizer. In particular the present invention relates to such compositions which form a sheet-shaped porous solid matrix. The invention also relates to methods for producing such compositions. The invention further relates to such compositions for use in treating human papillomavirus (HPV) infections and HPV-associated malignancies...

Cidofovir is obtained in different forms including amorphous cidofovir crystalline anhydrous cidofovir crystalline cidofovir monohydrate and crystalline cidofovir dihydrate including various polymorphs.

Cidofovir is obtained in different forms, including amorphous cidofovir, crystalline anhydrous cidofovir, crystalline cidofovir monohydrate, and crystalline cidofovir dihydrate, including various polymorphs.