THIS INVENTION RELATES TO THE DISCOVERY OF PRODRUGS OF 3-OR 5-SUBSTITUTED ANALOGUES OF THE SELECTIVE PLATELET LOWERING AGENT ANAGRELIDE WHICH HAVE REDUCED POTENTIAL FOR CARDIOVASCULAR SIDE-EFFECTS AND WHICH SHOULD THEREFORE LEAD TO IMPROVED PATIENT COMPLIANCE AND SAFETY IN THE TREATMENT OF MYELOPROLIFERATIVE DISEASES. MORE SPECIFICALLY, THE PRESENT INVENTION RELATES TO PRODRUGS OF CERTAIN IMIDAZOQUINAZOLINE DERIVATIVES WHICH HAVE UTILITY AS PLATELET LOWERING AGENTS IN HUMANS. THE COMPOUNDS OF TH...

The present invention relates to a novel process for producing quinazoline compounds which are useful in therapy. More specifically the compounds produced by the process of the invention are useful in the treatment of a number of cardiovascular diseases. The process of the invention provides 67-dichloro-15-dihydroimidazo[21-b]quinazolin 2(3H)-one more commonly known as anagrelide and its analogues in a clean and efficient manner.

The present invention relates to a novel process for producing anagrelide, 6,7-dichloro-1,5-dihydroimidazo[2,1-b]quinazolin 2(3H)-one, or certain analogues thereof. The process of the invention also provides improved processes for producing key intermediates required for the synthesis of anagrelide or certain analogues thereof.

The present invention relates to a novel process for producing anagrelide 67-dichloro-15-dihydroimidazo[21-b]quinazolin 2(3H)-one or certain analogues thereof. The process of the invention also provides improved processes for producing key intermediates required for the synthesis of anagrelide or certain analogues thereof.

593814 The present disclosure relates to a novel process for producing quinazoline compounds of formula XIwhich are useful in therapy. More specifically, the compounds produced by the process of the disclosure are useful in the treatment of a number of cardiovascular diseases. The process of the invention provides 6,7-dichloro-1,5- dihydroimidazo [2,1 -b] quinazolin 2 (3H)-one, more commonly known as anagrelide and its analogues. The compounds are produced by the reaction of compounds of formula...