The disclosure relates to compounds and compositions for bone formation fracture treatment bone grafting bone fusion cartilage maintenance and repair and methods related thereto. In certain embodiments the disclosure relates to compositions comprising one or more compound(s) disclosed herein such as clotrimazole honokiol magnolol tacrolimus pimecrolimus sirolimus everolimus temsirolimus spironolactone fluticasone fluticasone propionate fluticasone furoate linezolid telmisartan chlorambucil retin...

PURPOSE: A pharmaceutical composition containing 3-caffeoyl-4-dihydrocaffeoyl quinic acid(CDCQ) is provided to suppress cell basal lamina digesting enzyme MMP-2 and MMP-9 activities and prevent cancer cell metastasis. CONSTITUTION: A pharmaceutical composition for suppressing cancer metastasis contains 3-caffeoyl-4-dihydrocaffeoylquinic acid. The composition suppresses activity of MMP-2(matrix metalloprotease-2) or MMP-9(matrix metalloprotease-9). A health food for preventing metastasis contains...

Temperature sensitive immunoliposomes are provided to improve selectivity of drugs to target cells by binding an antibody recognizing an epitope specific to the target cell so that the drugs are transported to target cells such as cancer cells or target organs to kill cancer cells. Temperature-sensitive immunoliposomes consist of phospholipids of dipalmitoylphosphatidylcholine(DPPC) dimyristoylphosphatidylcholine(DMPC) and distearoylphosphatidylcholine(DSPC) and dioleoylphosphatidylethanolamine(...

The use of a dumb-bell-shaped linear, covalently closed DNA expression constructs with a double-stranded stem and single stranded loops located at both ends of the stem, wherein the stem of complementary deoxyribonucleic acids of a circular DNA strand comprises a promoter sequence, a coding sequence and a termination signal to be administered by jet injection for the treatment of cancer is disclosed. The dumbbell shaped DNA constructs may encode immunomodulating agents (e.g. cytokines such as TN...

FIELD: medicine. ^ SUBSTANCE: invention refers to a combined therapy which provides an anticancer effect of introducing to a person suffering cancer an effective amounts of (SP-4-3)-(cis-amminedichlorine-[2-metylpyridine]platinum (II) (ZD0473) or its prodrug and a non-platinum anticancer agent selected from a group consisting of taxane camptothecin gemcytabine capecitabine 5-fluorouracil vinorelbine topothecane anthracycline irinothecane etoposide vinblastine pemetrexede vindesine cyclophosphami...

Provided is the use of a nucleobase oligomer comprising the sequence of 5'- UGCACCCTGGATACCAUUU-3' (SEQ ID NO: 151) in the manufacture of a medicament for the treatment of cancer to be administered in combination with a chemotherapeutic agent selected from the imatinib, ZD1839, vinblastine, vincristine, vindesine, vinflunine, anhydrovinblastine, docetaxel, idarubicin, an antimetabolite carboplatin, and satraplatin.

The present invention provides a nano-micellar preparation containing vinca alkaloids antitumor agent for intravenous injection, which cincludes a therapeutically effective amount of vinca alkaloids antitumor agent (vinblastine, vincristine, vindesine and vinorelbine), a phosphatide derivatized with polyethylene glycol, together with pharmaceutically acceptable adjuvants. The preparation is prepared by encapsulating the medicament with a nano-micelle to obtain the nano-micellar preparation conta...

This invention concerns conjugates of transferrin albumin and polyethylene glycol consisting of native or thiolated transferrin or albumin or of polyethylene glycol (MW between approx. 5000 and 200 000) with at least one HS- HO- or H2N group and cytostatic compounds derived through maleinimide or N-hydroxysuccinimide ester-compounds such as doxorubicene daunorubicene epirubicene idarubicene mitoxandrone chlorambucil melphalan 5-fluorouracyl 5'-desoxy-5-fluorouridene thioguanine methotrexate pacl...