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ACADEMIA SINICA(6)
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Xianju Purui Pharmaceutical Co., Ltd.(3)
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公开号
公开日
申请号
申请日
1.
CN102028655B
2014/3/19
专利标题
:Oral formulations of zanamivir solid lipid nanoparticle and preparation method thereof
专利权人
:
Suzhou University
;
2.
US2014073804A1
2014/3/13
US201114001320
2011/6/13
专利标题
:PROCESS FOR THE PREPARATION OF ZANAMIVIR
专利权人
:
CHARAN GANPAT DAN SHIMBHU [IN]
;
TEHARE AJAY ONKARSINGH [IN]
;
SINGH KUMAR KEMLESH LAXMI [IN]
;
The present invention provides a process for preparing 5-(acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-D-glycero-D-galacto-non-enonic acid Formula (I), which process comprises reducing compound of Formula (IV) by Lindlar catalyst in presence of hydrogen to obtain compound of Formula (V). reacting compound of Formula (V) with pyrazole-1H-carboxamidine or its suitable salt to obtain compound of Formula (VIII). hydrolyzing the compound of Formula (VIII) to give compound of Fo...
3.
US20140073804A1
2014/3/13
专利标题
:Process for the preparation of zanamivir
专利权人
:
Cadila Healthcare Limited
;
The present invention provides a process for preparing 5-(acetylamino)-4-[(aminoiminomethyl)amino]-26-anhydro-345-trideoxy-D-glycero-D-galacto-non-enonic acid Formula (I) which process comprises reducing compound of Formula (IV) by Lindlar catalyst in presence of hydrogen to obtain compound of Formula (V). reacting compound of Formula (V) with pyrazole-1H-carboxamidine or its suitable salt to obtain compound of Formula (VIII). hydrolyzing the compound of Formula (VIII) to give compound of Formul...
4.
CN103520097A
2014/1/22
专利标题
:A kind of zanamivir injection and preparation method thereof
专利权人
:
5.
EP2678324A1
2014/1/1
EP20110749558
2011/6/13
专利标题
:PROCESS FOR THE PREPARATION OF ZANAMIVIR
专利权人
:
CADILA HEALTHCARE LTD [IN]
;
6.
CN103446051A
2013/12/18
CN20131376626
2013/8/26
专利标题
:Method for administrating preparations containing peramivir and/or derivatives thereof
专利权人
:
7.
CN103446078A
2013/12/18
CN20131376245
2013/8/26
专利标题
:Method for administrating preparations containing oseltamivir guanidyl carboxylate analogues and/or ethyl esters thereof
专利权人
:
8.
CN103435582A
2013/12/11
CN20131270340
2013/6/28
专利标题
:Laninamivir octanoate preparation method
专利权人
:
SHENZHEN NEPTUNUS PHARMACEUTIC
;
9.
CN102475695B
2013/12/11
专利标题
:Zanamivir capsule type inhalation aerosol powder and preparation method thereof
专利权人
:
Shangdong New Time Pharmaceutical Co., Ltd.
;
10.
WO2013155375A1
2013/10/17
WO2013US36308
2013/4/12
专利标题
:ENHANCED ANTI-INFLUENZA AGENTS CONJUGATED WITH ANTI-INFLAMMATORY ACTIVITY
专利权人
:
ACADEMIA SINICA
;
WONG CHI-HUEY [US]
;
FANG JIM-MIN
;
LIU KUNG-CHENG
;
JAN JIA-TSRONG
;
CHENG YIH-SHYUN E
;
CHENG TING-JEN R
;
Novel dual-targeted, bifunctional anti-influenza drugs formed by conjugation with anti-inflammatory agents are disclosed. Exemplary drugs according to the invention include caffeic acid (CA)-bearing zanamivir (ZA) conjugates ZA-7-CA (1), ZA-7-CA-amide (7) and ZA-7-Nap (43) for simultaneous inhibition of influenza virus neuraminidase and suppression of proinflammatory cytokines. Synthetic methods for preparation of these enhanced anti- influenza conjugate drugs are provided. The synthetic bifunct...
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