In the present invention there is disclosed a pharmaceutical composition containing cyclopeptide cyclo-(Arg-Gly-Asp-D-Phe-NMe-Val) and/or a physiologically acceptable salt thereof and at least one chemotherapeutic agent and/or physiologically acceptable salts thereof being selected from the group consisting of a) alkylating agents selected from a group consisting of busulfan carboplatin carmustine cisplatin cyclophosphamide dacarbazine ifosfamide and lomustine b) antibiotics selected from a grou...

The additive effect of combined intracranial carmustine ("BCNU") with intracranial temozolomide ("TMZ"), and particularly in combination with radiation ("XRT"), in the treatment of two rat intracranial glioma models, the 9L gliosarcoma and the F98 glioma, demonstrates that local delivery of both drugs, especially in combination with radiation, is far more effective than delivery of either drug alone or one systemically and one locally, either with or without radiation. The triple therapy showed ...

The additive effect of combined intracranial carmustine (“BCNU”) with intracranial temozolomide (“TMZ”) and particularly in combination with radiation (“XRT”) in the treatment of two rat intracranial glioma models the 9L gliosarcoma and the F98 glioma demonstrates that local delivery of both drugs especially in combination with radiation is far more effective than delivery of either drug alone or one systemically and one locally either with or without radiatio...