A process for making clofarabine comprising: fluorinating a compound of formula VII wherein each R4 is independently a hydroxy protecting group OR6 is a leaving group with a fluorinating agent in the presence of guanidine carbonate to give a compound of formula VIII: wherein R4 is as defined above; and deprotecting the compound of formula VIII to give the clofarabine.

Methods for treating neoplasia with combination of clofarabine and radiation are provided. Radiation therapies used in conjunction with clofarabine presents a synergistic effect in the treatment of cancers. The clofarabine sensitizes cells making them more susceptible to radiation therapy.

The present invention provides for the preparation [beta]-adenine nucleosides by coupling an adenine derivative containing an unprotected exocyclic amino group at the C-6 position and a blocked arabinofuranosyl derivative, in the presence of a base and solvent. The present invention also provides for the stereoselective preparation of 2-deoxy-[beta]-D-adenine nucleosides wherein a blocked 2-deoxy-[alpha]-D-arabinofuranosyl halide is coupled with the salt of an adenine derivative. The forgoing as...

588668 Disclosed is the use of helicin and its derivatives selected from 46-0-benzylidine-D-glucopyranosyloxy 2-ß-D-glucopyranosyloxy benzaldehyde 3-ß-D-glucopyranosyloxy benzaldehyde or 4-ß-D-glucopyranosyloxy benzaldehyde in the preparation of a medicament for treatment of cancer and wherein the medicament may further comprise a secondary agent selected from azacitidine bevacizumab bortezomib capecitabine cetuximab clofarabine dasatinib decitabine docetaxel emend erlotinib hydrochloride exemes...

The present invention relates to methods and pharmaceutical compositions for inhibiting influenza virus replication. More particularly, the present invention relates to a compound selected from the group consisting of Gemcitabine, Obatoclax Mesylate, Docetaxel, HA- 14, Alsterpaullone, GSK3B inhibitor VIII, GSK3B inhibitor XV, Indirubin 3'- monoxime, L glutathione reduced, Fluocinolone acetonide, Tirofiban, Topotecan hydrochloride, Clofarabine, Vinblastine, Menadione Crystalline and derivatives o...