Pharmaceutical composition comprising aflibercept, folinic acid, 5-fluorouracil (5-FU) and irinocetan (FOLFIRI) useful in the treatment of Colorectal cancer (CRC).

Pharmaceutical composition comprising aflibercept folinic acid 5-fluorouracil (5-FU) and irinocetan (FOLFIRI) useful in the treatment of Colorectal cancer (CRC).

FIELD: chemistry.SUBSTANCE: invention relates to novel 5-fluorouracil derivatives of general formula (I) or pharmaceutically acceptable salts thereof. In general formula(I) Rdenotes a hydrogen atom or a protective hydroxy group which is selected from a C-Caliphatic acyl group; C-Calicyclic acyl group; aromatic acyl group which is selected from a benzoyl group or a halogen-benzoyl group Rdenotes a lower alkoxy-lower alkyl group; X denotes CH or a nitrogen atom and Y denotes a halogen atom.EFFECT:...

The present invention addresses the problem of providing a useful production intermediate for producing 1-[2'-deoxy-4'-thio-1'-beta-D-ribofuranosyl]-5-fluorouracil and a production method using said intermediate. As a means for solving the problem, provided is compound (1) that is represented by formula (1) or a salt thereof. In formula (1), Bn represents a benzyl group.

The present invention provides antibiofilm composition comprising two or more agents selected from the group consisting of DispersinB(TM) 5-Fluorouracil Deoxyribonuclease I and Proteinase K for preventing growth and proliferation of biofilm-embedded microorganisms in wound care oral care and disease-related infections and methods of treatment in mammals. The invention further provides methods for preparing medical devices and wound care devices using an antibiofilm composition comprising two or ...

ABSTRACT - 600649 The disclosure relates to an anti-infective device comprising: (i) a catheter comprising a non-luminal exterior surface and a lumen surface