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标题标题2专利权人发明人附图摘要摘要2优先权号IPC专利类型
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公开号 公开日 申请号 申请日
1. EP2711000A1 2014/3/26 EP20130156234 2013/2/21
专利标题:Targeted liposomes 法律状态
专利权人Georgetown University;
The present invention is in the field of drug delivery and specifically cationic liposome-based drug delivery. In embodiments this invention provides methods of making ligand-targeted (e.g. antibody- or antibody fragment-targeted) liposomes useful for the delivery of liposomes to tumors including brain tumors. In embodiments the liposomes deliver temozolomide across the blood-brain barrier for treatment of primary or metastatic brain tumors. Additional cancers that can be treated with the liposo...


2. CN102579434B 2014/3/19
专利标题:The treatment brain cancer or in order to reduce the drug-fast medical composition of brain cancer cell to temozolomide 法律状态
专利权人China Medical University;


3. CN103626772A 2014/3/12
专利标题:The synthetic method of a kind of temozolomide and intermediate 法律状态
专利权人


4. CN102481288B 2014/2/19
专利标题:Contain temozolomide's pharmaceutical composition of amino acid stabilizers and preparation method thereof 法律状态


5. WO2014010948A1 2014/1/16 WO2013KR06157 2013/7/10
专利标题:Pharmaceutical composition comprising azathioprine as active ingredient for preventing or treating brain tumors or temodal-resistant glioblastomas 法律状态
The present invention relates to a pharmaceutical composition comprising azathioprine as an active ingredient for preventing or treating cancer or Temodal-resistant glioblastomas. The azathioprine according to the present invention not only effectively inhibits the proliferation of glioblastomas but also exhibits excellent effects in treating glioblastoma cancer cells that are resistant to Temodal (temozolomide) which is a conventional therapeutic agent for treating glioblastomas. Therefore the ...


6. CN102329319B 2014/1/15
专利标题:The crystal formation of temozolomide, its preparation method and medicinal compositions thereof 法律状态


7. CN103463630A 2013/12/25 CN20131228314 2006/11/2
专利标题:Concurrent chemotherapy and immunotherapy 法律状态
专利权人UNIV DUKE;UNIV TEXAS;


8. KR20130138779A 2013/12/19 KR20137009778 2011/9/22
专利标题:TOP2A INHIBITION BY TEMOZOLOMIDE USEFUL FOR PREDICTING GBM PATIENT'S SURVIVAL 法律状态


9. EP2374807B1 2013/12/18
专利标题:An improved process for the isolation of temozolomide 法律状态
专利权人Cipla Limited;
The present invention relates to a process for isolating temozolomide from an acidic solution containing temozolomide comprising; subjecting the acidic solution of temozolomide to a counter-current continuous liquid-liquid extraction using water immiscible solvent. The present invention also relates to a process for purifying temozolomide comprising refluxing temozolomide in an acetone-water mixture having a pH from 2.5 to 4.5 followed by recovering purified temozolomide.


10. CN103432085A 2013/12/11 CN20131360550 2013/8/19
专利标题:Temozolomide freeze-drying preparation containing amino acid solubilizer, and preparation method thereof 法律状态



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