The present invention relates to a pharmaceutical composition comprising Lipiodol and a molecule with anti-tumour activity and secondarily a hydroxyethyl starch. The present invention also relates to the use of the compositions according to the invention for treating cancer. According to one absolutely preferred embodiment, the pharmaceutical composition according to the invention comprises between 0.004% and 0.2% by weight of idarubicin, between 0.38% and 2.25% by weight of hydroxyethyl starch ...

The invention provides pharmaceutical compositions and method for inhibiting growth of prostatic adenocarcinoma stomach cancer breast cancer endometrial ovarian or other cancers of epithelial secretion or benign prostate hyperplasia (BPH). In one embodiment the pharmaceutical composition includes human rHuPSP94 antigenic portions thereof and functionally equivalent polypeptides thereof. In another embodiment the pharmaceutical composition includes a mixture of human rHuPSP94 antigenic portions t...

The patent application relates to a method for production of crystalline idarubicin hydrochloride comprising the steps (i) production of a mixture containing (a) idarubicin hydrochloride, (b) at least one alcohol selected from the group consisting of 1-butanol, 2-butanol, and 1-pentanol, and (c) water, and (ii) crystallization of idarubicin hydrochloride from this mixture.

The patent application relates to a method for producing crystalline idarubicin hydrochloride, comprising the steps of (i) preparing a mixture that contains (a) idarubicin hydrochloride, (b) at least one alcohol selected from the group consisting of 1-butanol, 2-butanol and 1-pentanol, and (c) water

The disclosure relates to compounds and compositions for bone formation fracture treatment bone grafting bone fusion cartilage maintenance and repair and methods related thereto. In certain embodiments the disclosure relates to compositions comprising one or more compound(s) disclosed herein such as clotrimazole honokiol magnolol tacrolimus pimecrolimus sirolimus everolimus temsirolimus spironolactone fluticasone fluticasone propionate fluticasone furoate linezolid telmisartan chlorambucil retin...

The invention provides pharmaceutical compositions and method for inhibiting growth of prostatic adenocarcinoma stomach cancer breast cancer endometrial ovarian or other cancers of epithelial secretion or benign prostate hyperplasia (BPH). In one embodiment the pharmaceutical composition includes human rHuPSP94 antigenic portions thereof and functionally equivalent polypeptides thereof. In another embodiment the pharmaceutical composition includes a mixture of human rHuPSP94 antigenic portions t...

PROBLEM TO BE SOLVED: To provide methods for the chemical synthesis of anthracycline compounds, more particularly, a method for the production of 4-demethoxydaunorubicin (idarubicin).

PURPOSE: A method for synthesizing 4-demethoxydaunorubicin(idarubicin) is provided to improve the yield of a final product and to ensure quick synthesis cycle. CONSTITUTION: A method for preparing 4-demethoxydaunorubicin or a salt thereof with a structure of chemical formula 1

The present invention relates to a method for the synthesis of 4-demethoxydaunorubicin (idarubicin) having the chemical structure of formula (I), which involves the demethylation of 3'-Prot-daunorubicin in the presence of a soft Lewis acid. The method of the present invention does not comprise cleavage of the glycosidic linkage at carbon C7, thus resulting in a faster synthesis cycle and an improved yield of the final product.

The present invention relates to a method for the synthesis of 4-demethoxydaunorubicin (idarubicin) having the chemical structure of formula (I), which involves the demethylation of 3'-Prot-daunorubicin in the presence of a soft Lewis acid. The method of the present invention does not comprise cleavage of the glycosidic linkage at carbon C7, thus resulting in a faster synthesis cycle and an improved yield of the final product.