In the present invention there is disclosed a pharmaceutical composition containing cyclopeptide cyclo-(Arg-Gly-Asp-D-Phe-NMe-Val) and/or a physiologically acceptable salt thereof and at least one chemotherapeutic agent and/or physiologically acceptable salts thereof being selected from the group consisting of a) alkylating agents selected from a group consisting of busulfan carboplatin carmustine cisplatin cyclophosphamide dacarbazine ifosfamide and lomustine b) antibiotics selected from a grou...

The invention relates to compositions containing nanoparticles and to uses o f said compositions for encapsulating therapeutically active substances in cel ls by means of nanoparticles with a particular coating. The particles are chemically formed in such a way as to enable a high intracellular absorption into the cells. The encapsulation requires no direct binding between nanoparticles and the therapeutically active substance. The encapsulation enables an increased efficiency of the substance w...

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to method of synthesis of 1-(2-chloroethyl)-3-cyclohexyl-1- nitrosourea known in pharmacy as antitumor preparation lomustine. By the proposed method lomustine is synthesized for some stages: by interaction of cyclohexylisocyanate with monoethanolamine in acetonitrile medium and feeding the reaction product directly to the next stage of reaction product treatment with thionyl chlioride in toluene medium in the presence of...