The invention discloses a method for the treatment of diseases particularly those diseases characterized by diminished or aberrant cellular function including AIDS cancer and Alzheimer's Disease. The method comprises administering a therapeutically effective amount of rosuvastatin enantiomer compounds in their (3R 5R) (3S 5R) or (3S 5S) configurations or pharmaceutically acceptable salts thereof. Biologically-active rosuvastatin enantiomer compounds with (3R 5R) (3S 5R) and (3S 5S) stereochemist...

The invention relates to commercially viable process for the synthesis of key intermediates for the preparation of statins, in particular Rosuvastatin and Pitavastatin or respective pharmaceutically acceptable salts thereof. A new simple and short synthetic route for key intermediates is presented which benefits from the use of cheap and readily available starting materials, by which the conventionally most frequently used DIBAL-H as reducing agent can be avoided.