The present invention relates to a solid pharmaceutical composition for preventing or treating cardiovascular disorders comprising amlodipine and losartan as active ingredients and a disintegrant which is a mixture of at least two components selected from the group consisting of sodium starch glycolate crosscarmellose sodium and crosspovidone which exhibits a high and stable level of amlodipine and losartan dissolution rates.

The present invention relates to a solid pharmaceutical composition for preventing or treating cardiovascular disorders comprising granular forms of amlodipine and losartan which are separated from each other and a stabilizing agent which has improved storage stability due to minimized interaction between amlodipine and losartan.

The present invention relates to a solid pharmaceutical composition for preventing or treating cardiovascular disorders comprising amlodipine and losartan as active ingredients and a disintegrant which is a mixture of at least two components selected from the group consisting of sodium starch glycolate crosscarmellose sodium and crosspovidone which exhibits a high and stable level of amlodipine and losartan dissolution rates.

594740 Disclosed herein is a solid pharmaceutical composition for preventing or treating cardiovascular disorders comprising granular forms of amlodipine and losartan which are separated from each other, and a stabilizing agent, wherein the stabilizing agent is an anti-oxidant selected from the group consisting of butylated hydroxytoluene, butylated hydroxyanisole, tocopherol, ascorbic acid, erythorbic acid, citric acid, ascorbyl palmitic acid, ethylene diamine tetracetic acid, sodium pyrosulfit...

594739 Disclosed herein is a pharmaceutical composition for preventing or treating cardiovascular disorders comprising amlodipine and losartan and a disintegrant which is a mixture of at least two components selected from the group consisting of sodium starch glycolate, crosscarmellose sodium and crosspovidone.

Abstract 594738 The present disclosure relates to a solid pharmaceutical composition for preventing or treating cardiovascular disorders comprising amlodipine or a pharmaceutically acceptable salt thereof and losartan or a pharmaceutically acceptable salt thereof, which exhibits high dissolution rates of amlodipine and losartan even under a low pH condition and improved storage stability.