The invention relates to compositions and formulations for intranasal/inhalation administration comprising phenoxybenzamine and/or related haloalkylamines, and methods of use thereof, for treatment of subjects suffering from acute and chronic pain syndromes, e.g., sustained relief of local and non-regional pain initiated or maintained by the sympathetic nervous system, either peripherally or centrally in subjects suffering, e.g., from reflex sympathetic dystrophy (RSD)/complex regional pain synd...

The invention provides methods for measuring concentrations of basic or neutral compounds, such as phenoxybenzamine, in biological samples, and methods for treating patients based on the compound concentrations in the biological samples from the patients.

The invention provides methods for measuring concentrations of basic or neutral compounds such as phenoxybenzamine in biological samples and methods for treating patients based on the compound concentrations in the biological samples from the patients.

The present invention relates to the use of a calmodulin inhibitor/antagonist, like bepridil, phenoxybenzamine, cetiedil, chlorpromazine or W7, for the preparation of a pharmaceutical composition for the treatment, amelioration and/or prevention of neurodegenerative disorders. Also means and methods for the prevention, amelioration and/or treatment of neurodegenerative disorders are described, wherein said calmodulin inhibitor/antagonist is to be administered to a subject in need of such a an pr...