The present invention relates to compounds for treatment that protects the endothelium, prevents pathologic thrombus formation in the microcirculation and preserves platelet number and function and thus may be related to treatment or prevention of ischemic events in patients with cardiovascular disease. The present invention is particularly useful for patients having or being at increased risk of development of an ischemic event such as an acute myocardial infarction and/or no-reflow phenomena a...

A medical device includes a structure configured for introduction to a vascular system of a patient. The structure including a surface having sodium nitroprusside and silver disposed thereupon. The sodium nitroprusside has a concentration sufficient to reduce thrombosis. To make the medical device a base material is impregnated with sodium nitroprusside the medical device is formed from the base material and the medical device is coated with an antimicrobial agent.

A medical device includes a structure configured for introduction to a vascular system of a patient. The structure including a surface having sodium nitroprusside and silver disposed thereupon. The sodium nitroprusside has a concentration sufficient to reduce thrombosis. To make the medical device, a base material is impregnated with sodium nitroprusside, the medical device is formed from the base material, and the medical device is coated with an antimicrobial agent.

The method for preventing the complications due to administration of the drugs belonging to the different groups comprises administration of Doxorubicine, sodium fluoride, sodium nitroprusside, ATP-LONG.

The invention relates to the use of 25-dihydroxybenzenesulphonic acid derivatives having general formula (I) in the production of medicaments that are used in therapeutics in order to potentiate the effects of inhibitors of phosphodiesterase-5 including sildenafil vardenafil and IC-351 apomorphine nitric oxide including amyl nitrate nitroglycerine nitroprusside nitrosothiol and nicorandil compounds that increase the cyclic GMP level in the penile tissue and other compounds that are intended to s...

FIELD: organic chemistry, biochemistry, enzymes. SUBSTANCE: invention can be used in biochemistry for study of regulatory effects of nitrogen oxide and mechanism of action of peroxide-containing sesquiterpenoids of artemisinine order on activity of soluble form of guanylate cyclase (sGC). Invention relates to artemisinine and its derivatives of the general formula (I): wherein if is a simple bond then R is OH, (lower alkyl)-hydroxy-group or OC(O)CH2CH2C(O)ONa