专利信息

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专利标题：PROCESS FOR THE PRODUCTION OF SITAGLIPTIN

A novel process is described for the synthesis of Sitagliptin, IUPAC name 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine, of formula (I).

专利标题：Process for the production of sitagliptin

专利权人：Chemo Iberica, S.a.;

A novel process is described for the synthesis of Sitagliptin IUPAC name 7-[(3R)-3-amino-1-oxo-4-(245-trifluorophenyl)butyl]-5678-tetrahydro-3-(trifluoromethyl)-124-triazolo[43-a]pyrazine of formula (I).

专利标题：New sitagliptin salt, its preparation method and pharmaceutical composition thereof

专利标题：Novel salts of sitagliptin, process for the preparation and pharmaceutical composition thereof

专利权人：Laurus Labs Private Ltd.;

The present invention relates to pharmaceutically acceptable acid addition salts of sitagliptin in particular anti-oxidant acid addition salts of sitagliptin and a process for its preparation. The present invention also provides a pharmaceutical composition using the pharmaceutically acceptable acid addition salts of sitagliptin.

专利标题：NOVEL SALTS OF SITAGLIPTIN, PROCESS FOR THE PREPARATION AND PHARMACEUTICAL COMPOSITION THEREOF

The present invention relates to pharmaceutically acceptable acid addition salts of sitagliptin, in particular anti-oxidant acid addition salts of sitagliptin and a process for its preparation. The present invention also provides a pharmaceutical composition using the pharmaceutically acceptable acid addition salts of sitagliptin.

专利标题：PROCESS FOR THE PRODUCTION OF SITAGLIPTIN

专利权人：CHEMO IBERICA SA [ES];

专利标题：Glucokinase activator compositions for the treatment of diabetes

专利权人：Transtech Pharma, Llc;

The present invention relates to pharmaceutical compositions comprising {2-[3-cyclohexyl-3-(trans-4-propoxy-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid (FRI-1) in combination with an anti-diabetic drug selected from the group consisting of metformin sitagliptin or exenatide. The present invention also relates to the use of the pharmaceutical compositions in restoring insulin sensitivity and treating type II diabetes including reducing body weight in subjects undergoing type II diabetes...

专利标题：Method of preparing sitagliptin and intermediates used therein

专利权人：Hanmi Science Co., Ltd.;

Disclosed are a novel simple and low-cost method for preparing sitagliptin as DPP-IV (dipeptidyl peptidase IV) inhibitor which is useful in treating type 2 diabetes mellitus and key intermediates used in said preparation of sitagliptin.

专利标题：The preparation of sitagliptin intermediate

专利标题：Glucokinase activator compositions for the treatment of diabetes

专利权人：Transtech Pharma, Llc;

当前查询条件: [药品] 包含 'Sitagliptin'

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!	专利类型	发明实用新型外观设计
!	公开号			CN1234
!	申请号			CN1234
!	专利标题		扩展	PHARMA
!	专利权人		扩展	pfizer
	发明人
!	申请日			yyyymmdd
!	公开日			yyyymmdd
	优先权号
!	摘要		扩展	PHARMA
	IPC			A01B

1. US2014081026A1	2014/3/20	US201214114781	2012/5/4
专利标题：PROCESS FOR THE PRODUCTION OF SITAGLIPTIN 专利权人：RASPARINI MARCELLO [IT];TUFARO ROBERTO ROCCO [IT];MINELLI COSIMA [IT];CHEMO IBERICA SA [ES]; A novel process is described for the synthesis of Sitagliptin, IUPAC name 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine, of formula (I).

2. US20140081026A1	2014/3/20	US14/114781	2012/5/4
专利标题：Process for the production of sitagliptin 专利权人：Chemo Iberica, S.a.; A novel process is described for the synthesis of Sitagliptin IUPAC name 7-[(3R)-3-amino-1-oxo-4-(245-trifluorophenyl)butyl]-5678-tetrahydro-3-(trifluoromethyl)-124-triazolo[43-a]pyrazine of formula (I).

3. CN103649090A	2014/3/19	CN2012804856	2012/10/12
专利标题：New sitagliptin salt, its preparation method and pharmaceutical composition thereof 专利权人：

4. US20140073791A1	2014/3/13	US13/985490	2012/10/12
专利标题：Novel salts of sitagliptin, process for the preparation and pharmaceutical composition thereof 专利权人：Laurus Labs Private Ltd.; The present invention relates to pharmaceutically acceptable acid addition salts of sitagliptin in particular anti-oxidant acid addition salts of sitagliptin and a process for its preparation. The present invention also provides a pharmaceutical composition using the pharmaceutically acceptable acid addition salts of sitagliptin.

5. US2014073791A1	2014/3/13	US201213985490	2012/10/12
专利标题：NOVEL SALTS OF SITAGLIPTIN, PROCESS FOR THE PREPARATION AND PHARMACEUTICAL COMPOSITION THEREOF 专利权人：INDUKURI VENKATA SUNIL KUMAR [IN];GORANTLA SEETA RAMANJANEYULU [IN];MUPPIDI VAMSEE KRISHNA [IN];CHAVA SATYANARAYANA [IN];LAURUS LABS PRIVATE LTD [IN]; The present invention relates to pharmaceutically acceptable acid addition salts of sitagliptin, in particular anti-oxidant acid addition salts of sitagliptin and a process for its preparation. The present invention also provides a pharmaceutical composition using the pharmaceutically acceptable acid addition salts of sitagliptin.

6. EP2705026A1	2014/3/12	EP20120727603	2012/5/4
专利标题：PROCESS FOR THE PRODUCTION OF SITAGLIPTIN 专利权人：CHEMO IBERICA SA [ES];

7. US20140066372A1	2014/3/6	US14/071976	2013/11/5
专利标题：Glucokinase activator compositions for the treatment of diabetes 专利权人：Transtech Pharma, Llc; The present invention relates to pharmaceutical compositions comprising {2-[3-cyclohexyl-3-(trans-4-propoxy-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid (FRI-1) in combination with an anti-diabetic drug selected from the group consisting of metformin sitagliptin or exenatide. The present invention also relates to the use of the pharmaceutical compositions in restoring insulin sensitivity and treating type II diabetes including reducing body weight in subjects undergoing type II diabetes...

8. AU2010308758B2	2014/3/6	AU20100308758	2010/10/19
专利标题：Method of preparing sitagliptin and intermediates used therein 专利权人：Hanmi Science Co., Ltd.; Disclosed are a novel simple and low-cost method for preparing sitagliptin as DPP-IV (dipeptidyl peptidase IV) inhibitor which is useful in treating type 2 diabetes mellitus and key intermediates used in said preparation of sitagliptin.

9. CN103608328A	2014/2/26	CN2012827947	2012/4/6
专利标题：The preparation of sitagliptin intermediate 专利权人：

10. WO2013173417A3	2014/2/20	WO2013US41076	2013/5/15
专利标题：Glucokinase activator compositions for the treatment of diabetes 专利权人：Transtech Pharma, Llc; The present invention relates to pharmaceutical compositions comprising {2-[3-cyclohexyl-3-(trans-4-propoxy-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid (FRI-1) in combination with an anti-diabetic drug selected from the group consisting of metformin sitagliptin or exenatide. The present invention also relates to the use of the pharmaceutical compositions in restoring insulin sensitivity and treating type II diabetes including reducing body weight in subjects undergoing type II diabetes...

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