POSITIVELY CHARGED WATER-SOLUBLE PRODRUGS OF ACETAMINOPHEN AND RELATED COMPOUNDS WITH VERY FAST SKIN PENETRATION RATE The novel positively charged pro-drugs of acetaminophen, acetaminosalol, and related compounds in the general formula (1) 'Structure 1' were designed and synthesized. The positively charged amino groups of these pro-drugs not only largely increases the solubility of the drugs, but also bonds to the negative charge on the phosphate head group of membranes and pushes the pro-drug i...

A composition comprising reduced glutathione and acetaminophen and preparation method thereof. The main drug of the composition is 0.1%-99.9% reduced glutathione, 99.9%-1% acetaminophen. The composition can be formulated as tablets, sustained / controlled release formulations, capsules, pills, syrups, films, granules, oral solutions, oral suspensions, oral emulsions, oral powders and any other pharmaceutically acceptable dosage forms. The composition can effectively prevent damage and necrosis o...

The invention relates to a composition that includes a first agent selected including an agent that possesses anti-inflammatory activity or acetaminophen, phenacetin, tramadol and the like

The present invention relates to compositions for the modulation of inflammation in connective tissues in humans and animals and the modulation of markers of such inflammation including COX-2 TNF-α IL- 1&bgr; iNOS p38 and chemokines comprising any or all of anabolic anti-catabolic anti-oxidant and analgesic agents including aminosugars S-adenosylmethionine arachadonic acid GAGs including pentosan collagen type II tetracyclines or tetracycline-like compounds diacerin super oxide dismutase L...

The present disclosure provides an extended release pharmaceutical composition comprising oxycodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval. Also provided are methods for reducing the risk of acetaminophen-induced hepatic damage in a subject being treated with an acetaminophen containing composition, as well as methods for treating pain in a subject in need thereof.

This invention relates to novel acetylcysteine compositions in solution comprising acetylcysteine and which are substantially free of metal chelating agents such as EDTA. Further this invention relates to methods of making and using the acetylcysteine compositions. The present compositions and methods are designed to improve patient tolerance and compliance while at the same time maintaining the stability of the pharmaceutical formulation. The compositions and methods of this invention are usefu...