Those in need of nitroglycerin (GTN) therapy who have polymorphism in the mtALDH gene e.g. those of Asian descent for whom this polymorphism is common and/or who are being treated with or ingesting or exposed to mtALDH inhibitor are treated with GTN in combination with agent which converts GTN to product which is metabolized without mtALDH activity e.g. N-acetylcysteine.

This invention relates to novel acetylcysteine compositions in solution comprising acetylcysteine and which are substantially free of metal chelating agents such as EDTA. Further this invention relates to methods of making and using the acetylcysteine compositions. The present compositions and methods are designed to improve patient tolerance and compliance while at the same time maintaining the stability of the pharmaceutical formulation. The compositions and methods of this invention are usefu...

The present invention provides a controlled-release composition which provides a therapeutically effective plasma concentration of N-acetylcysteine over prolonged period of time. The present invention also includes the use of the controlled-release composition either alone or in combination with at least one additional active agent for reduction of vascular inflammation marker and treatment of diseases conditions and/or symptoms associated with systemic and/or vascular inflammation in a patient....

The present invention provides a controlled-release composition which provides a therapeutically effective plasma concentration of N-acetylcysteine over prolonged period of time. The present invention also includes the use of the controlled-release composition, either alone or in combination with at least one additional active agent, for reduction of vascular inflammation marker and treatment of diseases, conditions, and/or symptoms associated with systemic and/or vascular inflammation in a pati...

Combination of cannabidiol (CBD) with therapeutic hypothermia for use in the treatment of neuroprotection or astroprotection is provided. Preferably the neuroprotection or astroprotection to be treated is hypoxic ischemia, preferably, hypoxic-ischemic encephalopathy (HIE), in particular newborn hypoxic-ischemic encephalopathy (NHIE), stroke or cardiac arrest. The CBD may be in the form of a plant extract, isolated or pure form. The combination treatment of cannabidiol and therapeutic hypothermia...

Compositions comprising isosilybin B and optionally additional protective agents selected from methylsulfonylmethane (MSM), phosphatidylcholine (PC), cysteine (Cys), seleno-cysteine (Se-Cys), ribose-cysteine (RibCys), N-acetylcysteine (NAC), N- acetylcysteine-amide (AD4), methionine (Met) and S-adenosylmethionine (SAM) for use in reducing and / or preventing drug- induced toxicity, such as acetaminophen-induced toxicity. Said compositions further comprising acetaminophen for use as safe formulat...