The present invention is directed to methods and compositions for topical administration of acitretin. More specifically, the present invention is related to methods and compositions for the treatment or prevention or reduction of symptoms or signs of dermatological conditions using acitretin in a topical administration. More specifically, the present invention is related to methods and compositions containing acitretin which are effective for the treatment or prevention or reduction of symptoms...

The present invention is directed to methods and compositions for topical administration of acitretin. More specifically, the present invention is related to methods and compositions for the treatment or prevention or reduction of symptoms or signs of dermatological conditions using acitretin in a topical administration. More specifically, the present invention is related to methods and compositions containing acitretin which are effective for the treatment or prevention or reduction of symptoms...

The present invention is directed to methods and compositions for topical administration of acitretin. More specifically the present invention is related to methods and compositions for the treatment or prevention or reduction of symptoms or signs of dermatological conditions using acitretin in a topical administration. More specifically the present invention is related to methods and compositions containing acitretin which are effective for the treatment or prevention or reduction of symptoms o...

The disclosure relates to compounds and compositions for bone formation fracture treatment bone grafting bone fusion cartilage maintenance and repair and methods related thereto. In certain embodiments the disclosure relates to compositions comprising one or more compound(s) disclosed herein such as clotrimazole honokiol magnolol tacrolimus pimecrolimus sirolimus everolimus temsirolimus spironolactone fluticasone fluticasone propionate fluticasone furoate linezolid telmisartan chlorambucil retin...

The present invention provides unique, efficacious, inexpensive, safe, reliable, convenient, minimally bitter, skin protecting and penetrating, easy-to-administer base compositions and active agent-containing compositions, such as those including hydrocortisone, and related production and topical application methods, for treating the skin of mammals for a wide variety of different dermatologic conditions, disorders and diseases, such as inflammation, redness, cracking, insect bites, dryness, all...

The invention relates to a process for the preparation of substantially pure Acitretin which comprises the following steps:a) salifying crude Acitretin with an amine of formula (II)         R1R2R3N     (II)wherein each of R1 R2 and R3 is independently hydrogen a C1-C6 alkyl group a C3-C8 cycloalkyl group a phenyl morpholino or pyridino group in the presence of an alcohol or water-alcohol solvent; andb) adding an organic acid to the salt obtained in step a).

Processes and systems for the preparation of substantially pure acitretin based on reacting crude acitretin and an amine in presence of a suitable solvent to provide a salt that is then reacted with an organic acid to obtain substantially pure acitretin.

Preparation of etretinate (I) comprises: (a) reacting acitretin (II) with an active reagent which is 11'-carbonyldiimidazole 11'-thiocarbonyldiimidazole or thionyl diimidazole to give 1-(3H-imidazole-1-yl)-37-dimethyl-9-(2346-tetramethyl-phenyl)-non a-2468-tetraen-1-one (III); and (b) reacting (III) with ethanol and/or an alkali or alkaline earth ethanolate to give a reaction mixture containing (I). - ACTIVITY : Antipsoriatic; Dermatological. - MECHANISM OF ACTION : None given.

The present invention relates to stable pharmaceutical compositions of acitretin with significantly enhanced bioavailability characteristics. The pharmaceutical compositions include a micronized solid dispersion of acitretin with one or more surface modifiers. Also provided are processes of preparing the compositions by aqueous grinding or milling of acitretin in presence of a hydrophilic surface modifier.

A process for the preparation of substantially pure acitretin of Formula (I) is provided: the process comprising (a) contacting a salt of acitretin with one or more solvents; and (b) isolating substantially pure acitretin from the product of step (a).