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LES LABORATOIRES SERVIER(441)
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公开号
公开日
申请号
申请日
1.
US20140088197A1
2014/3/27
US14/006484
2012/3/22
专利标题
:Mixed crystal agomelatine (form viii), preparation method and use thereof and pharmaceutical composition containing same
专利权人
:
LES LABORATORIES SERVIER
;
The present invention provides a mixed crystalline form VIII of agomelatine its method of preparation application and pharmaceutical composition. The said mixed crystal consists mainly of crystalline form VI of agomelatine. The said mixed crystalline form is stable and has good reproducibility. Through stability tests it has been found to be superior to the crystalline form VI in terms of stability. As a result the crystalline form VIII of the present invention possesses advantages in pharmaceut...
2.
WO2014040228A1
2014/3/20
WO2012CN81250
2012/9/11
专利标题
:STABILISED AMORPHOUS FORM OF AGOMELATINE, A PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT
专利权人
:
SERVIER LAB [FR]
;
SHANGHAI INST PHARM INDUSTRY [CN]
;
LAFARGUE DAVID [FR]
;
LYNCH MICHAEL [FR]
;
POIRIER CECILE [FR]
;
LETELLIER PHILIPPE [FR]
;
PEAN JEAN-MANUEL [FR]
;
LUO YING [CN]
;
SHAN HANBIN [CN]
;
SHEN YUHUI [CN]
;
The present invention relates to the stabilised amorphous form of the compound of formula (I), to a process for its preparation and also to pharmaceutical compositions or medicaments containing it.
3.
WO2014041015A1
2014/3/20
WO2013EP68792
2013/9/11
专利标题
:STABILISED AMORPHOUS FORM OF AGOMELATINE, A PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT.
专利权人
:
SERVIER LAB [FR]
;
SHANGHAI INST PHARM INDUSTRY [CN]
;
Stabilised amorphous form of the compound of formula (I): Medicaments.
4.
CN103623423A
2014/3/12
CN20131624494
2013/11/29
专利标题
:Agomelatine clathrate, its preparation method and application thereof
专利权人
:
5.
CN103251567B
2014/3/12
CN20131219836
2013/6/5
专利标题
:A kind of agomelatine tablet and preparation method thereof
专利权人
:
Chongqing Fortune Pharmaceutical Co., Ltd.
;
6.
EP2703383A1
2014/3/5
EP20130179063
2013/8/2
专利标题
:Process for the preparation of agomelatine
专利权人
:
PROCOS SPA [IT]
;
Disclosed is a process for the synthesis of Agomelatine (1), N-(2-(7-methoxynaphthalen-1-yl)ethyl)acetamide from ethyl 2-(7-methoxynaphthalen-1-yl)acetate (4). Said synthesis method is particularly advantageous compared with known procedures because it uses low-cost reagents under mild reaction conditions and allows the isolation of a product with excellent yields and quality.
7.
EP2176214B1
2014/3/5
EP20080842551
2008/8/1
专利标题
:Novel method for the synthesis of (7-methoxy-1-naphthyl)acetonitrile and application in the synthesis of agomelatine
专利权人
:
LES LABORATOIRES SERVIER
;
8.
HK1141004A1
2014/2/21
HK20100107579
2010/8/9
专利标题
:NEW PROCESS FOR THE SYNTHESIS OF AGOMELATINE
专利权人
:
SERVIER LAB [FR]
;
9.
US2014051887A1
2014/2/20
US201214114211
2012/4/25
专利标题
:PHARMACEUTICALLY ACCEPTABLE COCRYSTALS OF N-[2-(7-METHOXYL-1-NAPHTYL)ETHYL]ACETAMIDE AND METHODS OF THEIR PREPARATION
专利权人
:
MILLER GARY JAMES [GB]
;
RIDVAN LUDEK [CZ]
;
RICHTER JINDRICH [CZ]
;
DAMMER ONDREJ [CZ]
;
CHVOJKA TOMAS [CZ]
;
PEKAREK TOMAS [CZ]
;
HEYSE WINFRIED [DE]
;
NAGEL NORBERT [DE]
;
The present invention relates to novel solid forms of agomelatine (I), specifically novel phaamaceutically acceptable cocrystals thereof, as well as to methods of preparing them. Three pharmaceutically acceptable cocrystals of (I) that have physico-chemical properties acceptable for pharmaceutical development were obtained.
10.
CN102452951B
2014/2/19
CN20101517770
2010/10/25
专利标题
:Agomelatine and pharmaceutical composition thereof
专利权人
:
Tianjin Taipu Pharmaceutical Science & Technologydevelopment Co., Ltd.
;
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