FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to psychiatry, and concerns treating adaptation disorders in patients with a risk of suicidality. That is ensured by determining blood serotonin and melatonin, and if the derived relation is 1.2, an integrated therapy involving drug-induced and psychotherapeutic exposure according to the following procedure is required. Haloperidol 0.375-0.5 mg is administered 3 times a day for two weeks

Uso de alprazolam para la preparación de un medicamento destinado al tratamiento del insomnio primario mediante administración sublingual.

Disclosed is a composition comprising alprazolam for treating primary insomnia and insomnia associated with anxiety states and the corresponding use and method comprising the administration of alprazolam sublingual tablets having a disintegration time lower than 30 seconds and having the alprazolam preferably in non-crystalline or partially crystalline form according to the X-ray diffraction crystallography expanded for the position delta 9-12.5 (2 theta) to a patient suffering from said disorde...

The present invention is directed towards the preparation of extended release Alprazolam formulation. The formulation thus obtained provides an efficient mode of delivery of Alprazolam in a continuous manner.

The present invention describes the use of pharmaceutical compounds in pharmaceutical compositions for sublingual administration including as active ingredient thereof an agonist of the central receptor of benzodiazepinics chosen among diazepam lorazepam bromazepam triazolam alprazolam flunitrazepam nitrazepam and midazolam maleate in a mixture with a pharmaceutical excipient consisting of at least 70% of the weight of the final formulation containing 40-45% by weight of lactose 15-27% by weight...

The present invention comprises a nanoparticulate composition comprising (a) a benzodiazepine having an effective average particle size of less than about 2000 nm wherein the benzodiazepine is selected from the group consisting of alprazolam brotizolam chlordiazepoxide clobazam clonazepam clorazepam demoxazepam flumazenil flurazepam halazepam midazolam nordazepam medazepam diazepam nitrazepam oxazepam midazepam prazepam quazepam triazolam temazepam loprazolam pharmaceutically acceptable salts an...