Described are compounds and methods useful for selectively targeting cancer stem cells. The compounds preferentially induce differentiation and/or reduce the proliferation of cancer stem cells relative to normal stem cells. Compounds useful for selectively targeting cancer stem cells include polyene macrolides such as Nystatin or Amphotericin B analogs thereof and pharmaceutically acceptable salts thereof.

A method of ameliorating amphotericin treatment side effects in a mammal that comprises administering a therapeutically effective amount of a formulation that comprises a polyene active ingredient that includes amphotericin B wherein the amphotericin B compound is present in terms of polyene content in an amount greater than 90% and non-amphotericin B polyene compounds are present in an amount of no greater than 10% and a pharmaceutically effective carrier; and administering a therapeutically ef...

The present invention relates to: a water-soluble solid composition and an aqueous composition, each of which contains amphotericin B and a fatty acid polyethylene glycol

Complexes The invention provides aprocess for the preparation of a complex of Amphotericin B with poly(glutamic acid), which comprises the steps of i) mixing Amphotericin B with poly(glutamic acid) in the presence of water to form an aqueous solution of a complex of Amphotericin B with poly(glutamic acid)

The invention provides semisynthetic N-substituted derivatives of the antifungal antibiotic Amphotericin B and water soluble salts and complexes, pharmaceutical compositions and plant and building treatment products comprising the derivatives and their use as antifungal antibiotics.

FIELD: medicine, pharmaceutics.SUBSTANCE: present invention refers to medicine, pharmaceutics and nanotechnologies, and more specifically to a method for preparing nanosized amphotericin B for coating aluminosilicate nanotubes, used as a poorly soluble polyene macrocyclic antibiotic widely used for treating fungal diseases. What is presented is the method for preparing nanosized amphotericin B by mixing a solution of amphotericin B in dimethyl sulphoxide at room temperature with the aluminosilic...

The present invention comprises compositions and formulations comprising amphotericin B compositions and formulations comprising amphotericin B with one or more excipients methods of making amphotericin B compositions and formulations as well as systems for using amphotericin B compositions and formulations. Also provided are pharmaceutical compositions comprising the formulation methods of administering the pharmaceutical compositions and methods of treating patients with the pharmaceutical com...