专利信息

首页 1 2 3 4 5 6 下页尾页共 134 条记录, 当前第1/14页。

专利标题：PROCESS FOR THE PREPARATION OF A STABLE POLYMORPHIC FORM OF ATOVAGUONE

The present invention provides a process for the preparation of a stable polymorph III of Atovaquone exhibiting characteristic peaks (expressed in degrees 2theta+-0.2 DEG theta) at about 6.9, 9.6, 14.1, 14.7, 17.0, 18.5, 19.1, 19.9, 20.3, 22.0, 22.6, 23.2, 24.2, 26.8, and 28.5, which comprises: (a) providing a sample of Atovaquone particles

专利标题：A kind of preparation method of atovaquone

专利标题：Novel process for selective isolation and purification of 2-[4-(4-chlorophenyl) cyclohexyl]-3-chloro-1, 4-naphthoquinone and atovaquone

The present invention relates to an improved method for preparation and purification of atovaquone and its intermediate product. The present invention claims for an improved method for preparation and purification of the intermediate trans-2-[4-(4-chlorophenyl)cyclohexyl]-3-chloro-14-naphthoquinone(II) of formula-II and also preparation of stable form of 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-14-naphthoquinone(I) Atovaquone of formula - I and selective purification of trans-2-[4-(4-chl...

专利标题：Process for the preparation of atovaquone

专利权人：GLAXO GROUP LIMITED;

Disclosed herein is novel process for preparation of atovaquone which process includes reacting 1H-2-benzopyran-14(3H)-dione with 4-(4-chlorophenyl)cyclohexanecarbaldehyde. The invention further discloses novel intermediates useful in the preparation of atovaquone.

专利标题：PROCESS FOR THE PREPARATION OF ATOVAQUONE

专利权人：GLAXO GROUP LTD [GB];

专利标题：PROCESS FOR THE PREPARATION OF ATOVAQUONE

Disclosed herein is novel process for preparation of atovaquone, which process includes reacting 1H-2-benzopyran-1,4(3H)-dione with 4-(4-chlorophenyl)cyclohexanecarbaldehyde. The invention further discloses novel intermediates useful in the preparation of atovaquone.

专利标题：Process for the preparation of atovaquone

专利权人：GLAXO GROUP LIMITED;

专利标题：Novel process for selective isolation and purification of 2-[4-(4-chlorophenyl) cyclohexyl]-3-chloro-1, 4-naphthoquinone and atovaquone

专利标题：''3-(5-methyl-2-oxo-l, 3-dioxol-4-yl) methyloxy-2- trans-[(4-chloro phenyl) cyclohexyl] [1,4]naphthaquinone"-atovaquone prodrug

专利权人：Alkem Laboratories Ltd.;

The present invention relates to atovaquone prodrug compound of formula (I). Accordingly present invention provides a process involving condensation of Atovaquone (II) with 5-methyl-4- chloromethyl dioxalone (III) in suitable solvent system and optionally followed by distillation and crystallization to provide Atovaquone prodrug compound of formula (I) in high yields purity and suitable for large-scale manufacture.

专利标题：''3-(5-METHYL-2-OXO-L, 3-DIOXOL-4-YL) METHYLOXY-2- TRANS-[(4-CHLORO PHENYL) CYCLOHEXYL] [1,4]NAPHTHAQUINONE"-ATOVAQUONE PRODRUG

The present invention relates to atovaquone prodrug compound of formula (I). Accordingly, present invention provides a process involving condensation of Atovaquone (II) with 5-methyl-4- chloromethyl dioxalone (III) in suitable solvent system and optionally followed by distillation and crystallization to provide Atovaquone prodrug compound of formula (I) in high yields, purity, and suitable for large-scale manufacture.

当前查询条件: [药品] 包含 'Atovaquone'

	查询范围	在当前结果中查询
!	专利类型	发明实用新型外观设计
!	公开号			CN1234
!	申请号			CN1234
!	专利标题		扩展	PHARMA
!	专利权人		扩展	pfizer
	发明人
!	申请日			yyyymmdd
!	公开日			yyyymmdd
	优先权号
!	摘要		扩展	PHARMA
	IPC			A01B

1. US2014073816A1	2014/3/13	US201214005123	2012/3/14
专利标题：PROCESS FOR THE PREPARATION OF A STABLE POLYMORPHIC FORM OF ATOVAGUONE 专利权人：BAIDOSSI WAEL [IL];SOUDAH TERESE [IL];CYJON ROSA [IL];TARO PHARMA IND [IL]; The present invention provides a process for the preparation of a stable polymorph III of Atovaquone exhibiting characteristic peaks (expressed in degrees 2theta+-0.2 DEG theta) at about 6.9, 9.6, 14.1, 14.7, 17.0, 18.5, 19.1, 19.9, 20.3, 22.0, 22.6, 23.2, 24.2, 26.8, and 28.5, which comprises: (a) providing a sample of Atovaquone particles

2. CN103570521A	2014/2/12
专利标题：A kind of preparation method of atovaquone 专利权人：

3. WO2013098832A4	2013/12/5
专利标题：Novel process for selective isolation and purification of 2-[4-(4-chlorophenyl) cyclohexyl]-3-chloro-1, 4-naphthoquinone and atovaquone 专利权人：Dishman Pharmaceuticals & Chemicals Ltd.; The present invention relates to an improved method for preparation and purification of atovaquone and its intermediate product. The present invention claims for an improved method for preparation and purification of the intermediate trans-2-[4-(4-chlorophenyl)cyclohexyl]-3-chloro-14-naphthoquinone(II) of formula-II and also preparation of stable form of 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-14-naphthoquinone(I) Atovaquone of formula - I and selective purification of trans-2-[4-(4-chl...

4. US8598387B2	2013/12/3
专利标题：Process for the preparation of atovaquone 专利权人：GLAXO GROUP LIMITED; Disclosed herein is novel process for preparation of atovaquone which process includes reacting 1H-2-benzopyran-14(3H)-dione with 4-(4-chlorophenyl)cyclohexanecarbaldehyde. The invention further discloses novel intermediates useful in the preparation of atovaquone.

5. EP2651868A2	2013/10/23	EP20110805451	2011/12/13
专利标题：PROCESS FOR THE PREPARATION OF ATOVAQUONE 专利权人：GLAXO GROUP LTD [GB];

6. US2013267717A1	2013/10/10	US201113993683	2011/12/13
专利标题：PROCESS FOR THE PREPARATION OF ATOVAQUONE 专利权人：DWYER ANDREW NEIL [SG];GORDON ANDREW [GB];URQUHART MICHAEL [GB];GLAXO GROUP LTD [GB]; Disclosed herein is novel process for preparation of atovaquone, which process includes reacting 1H-2-benzopyran-1,4(3H)-dione with 4-(4-chlorophenyl)cyclohexanecarbaldehyde. The invention further discloses novel intermediates useful in the preparation of atovaquone.

7. US20130267717A1	2013/10/10
专利标题：Process for the preparation of atovaquone 专利权人：GLAXO GROUP LIMITED; Disclosed herein is novel process for preparation of atovaquone which process includes reacting 1H-2-benzopyran-14(3H)-dione with 4-(4-chlorophenyl)cyclohexanecarbaldehyde. The invention further discloses novel intermediates useful in the preparation of atovaquone.

8. WO2013098832A3	2013/10/10
专利标题：Novel process for selective isolation and purification of 2-[4-(4-chlorophenyl) cyclohexyl]-3-chloro-1, 4-naphthoquinone and atovaquone 专利权人：Dishman Pharmaceuticals & Chemicals Ltd.; The present invention relates to an improved method for preparation and purification of atovaquone and its intermediate product. The present invention claims for an improved method for preparation and purification of the intermediate trans-2-[4-(4-chlorophenyl)cyclohexyl]-3-chloro-14-naphthoquinone(II) of formula-II and also preparation of stable form of 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-14-naphthoquinone(I) Atovaquone of formula - I and selective purification of trans-2-[4-(4-chl...

9. WO2013093937A3	2013/8/15
专利标题：''3-(5-methyl-2-oxo-l, 3-dioxol-4-yl) methyloxy-2- trans-[(4-chloro phenyl) cyclohexyl] [1,4]naphthaquinone"-atovaquone prodrug 专利权人：Alkem Laboratories Ltd.; The present invention relates to atovaquone prodrug compound of formula (I). Accordingly present invention provides a process involving condensation of Atovaquone (II) with 5-methyl-4- chloromethyl dioxalone (III) in suitable solvent system and optionally followed by distillation and crystallization to provide Atovaquone prodrug compound of formula (I) in high yields purity and suitable for large-scale manufacture.

10. WO2013093937A2	2013/6/27	WO2012IN00613	2012/9/14
专利标题：''3-(5-METHYL-2-OXO-L, 3-DIOXOL-4-YL) METHYLOXY-2- TRANS-[(4-CHLORO PHENYL) CYCLOHEXYL] [1,4]NAPHTHAQUINONE"-ATOVAQUONE PRODRUG 专利权人：ALKEM LAB LTD [IN];SANJAY SUKUMAR SARALAYA [IN];AKSHAYA KUNJYANNAYA [IN];SHASHIPRABHA [IN];SHRIDHARA KANAKAMAJALU [IN];KOTHAPALLI SUNDARRAJA RAO [IN];KUPPUSWAMY NAGARAJAN [IN]; The present invention relates to atovaquone prodrug compound of formula (I). Accordingly, present invention provides a process involving condensation of Atovaquone (II) with 5-methyl-4- chloromethyl dioxalone (III) in suitable solvent system and optionally followed by distillation and crystallization to provide Atovaquone prodrug compound of formula (I) in high yields, purity, and suitable for large-scale manufacture.

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