1. Penicillin reverses resistance of mycobacterium to INH. 2. Penicillin as claimed in claim 1 can be a broad spectrum penicillin or a narrow spectrum penicillin. 3. Penicillin as claimed in claim 1 and 2 can be any single penicillin or combination of more than one penicillin. 4. Penicillin as claimed in claim 1 to 3 can have activity against beta-lactamase producing organism. 5. Penicillin as claimed in claim 1 to 3 can have activity against penicillinase producing organism. 6. Penicillin as cl...

1. The method of treating drug-resistant mycobacterial infection in an animal comprising administration to the said animal Penicillin and isoniazid (INH). 2. The method of claim 1 wherein penicillin is administered simultaneously with INH. 3. The method as claimed in claim 1 wherein penicillin and INH are administered sequentially. 4. The method as claimed in claim 1 to 3 wherein penicillin can be a broad spectrum penicillin or a narrow spectrum penicillin. 5. The method as claimed in claim 1 to...

A process for purifying a solution of an ampicillin pro-drug e.g. bacampicillin or an acid addition salt thereof which comprises a step wherein a crude solution thereof is subjected to an evaporation which is controlled by the evaporation rate of the organic solvent such that a continous operation is accomplished for the crystallization of the desired purified pro-drug ester or salt thereof. Said crystallization is preferably preceded by an aqueous phase extraction and/or an organic phase extrac...

Applicants have developed a process for purifying an ampicillin pro-drug ester e.g. bacampicillin or an acid addition salt thereof of formula I.The process comprises a step wherein a crude solution of the pro-drug ester is subjected to an evaporation which is controlled by the evaporation rate of the organic solvent such that a continuous operation is accomplished for the crystallization of the desired purified pro-drug ester or salt thereof.Said crystallization is preferably preceded by an aque...

alpha -Bromo diethylcarbonate is used to prepare ethylcarbonyloxyethyl esters of penicillins and caphalosporins.The amino group in ampicillin can first be protected by reaction with an acetoacetate derivative and the protecting group removed after the esterification step. alpha -Bromo diethylcarbonate can be used without an esterification catalyst and is obtained by reacting acetaldehyde with carbonyl bromide followed by reaction with ethanol or by a halogen exchange reaction with the correspon...

alpha -Bromo diethylcarbonate is used to prepare ethylcarbonyloxyethyl esters of penicillins and caphalosporins.The amino group in ampicillin can first be protected by reaction with an acetoacetate derivative and the protecting group removed after the esterification step. alpha -Bromo diethylcarbonate can be used without an esterification catalyst and is obtained by reacting acetaldehyde with carbonyl bromide followed by reaction with ethanol or by a halogen exchange reaction with the correspon...