A method and composition are provided for the treatment of an anorectal disorder and for controlling the pain associated therewith. The method comprises administering to a subject in need of such treatment therapeutically effective amounts of a calcium channel blocker either alone or together with a nitric oxide donor. Amlodipine anipamil barnidipine benidipine bepridil darodipine diltiazem efonidipine felodipine isradipine lacidipine lercanidipine lidoflazine manidipine mepirodipine nicardipine...

A method and composition are provided for the treatment of an anorectal disorder and for controlling the pain associated therewith. The method comprises administering to a subject in need of such treatment therapeutically effective amounts of a calcium channel blocker either alone or together with a nitric oxide donor. Amlodipine anipamil barnidipine benidipine bepridil darodipine diltiazem efonidipine felodipine isradipine lacidipine lercanidipine lidoflazine manidipine mepirodipine nicardipine...

The present invention relates to the use of rapamycin derivatives and ethers of N- propanolamines for decreasing infection by a pathogen. More particularly, the invention relates to the use of O-alkylated rapamycin derivatives, as well as bepridil, for decreasing viral infection.

A method for treating coronavirus infection by administering to a subject in need of the treatment an effective amount of one or more of the following compounds: aklavin sanguinarine amiodarone chlorpromazine clomiphene dihydroergotamine dipyridamole emetine ephedrine prochlorperazine promazine propiomazine aminacrine fluphenazine fenoterol peruvoside proglumide atenolol nerifolin nefopam cycloheximide avermectin B1 bepridil cinnarizine ethisterone pararosaniline methylbenzethonium niclosamide p...

The present invention is a method of treating or preventing mixed and/or manic episodes associated with bipolar I disorder or memory and/or cognitive impairment associated therewith in a patient in need thereof by administering an effective amount of at least one calcium channel modulator selected from (1 ) amlodipine bepridil clevidipine felodipine isradipine lacidipine lercanidipine manidipine niguldipine nilvadipine nisoldipine or nitrendipine or (2) the R-enantiomer of a 14-dihydropyridine c...

A method and composition are provided for the treatment of an anorectal disorder and for controlling the pain associated therewith. The method comprises administering to a subject in need of such treatment therapeutically effective amounts of a calcium channel blocker either alone or together with a nitric oxide donor. Amlodipine anipamil barnidipine benidipine bepridil darodipine diltiazem efonidipine felodipine isradipine lacidipine lercanidipine lidoflazine manidipine mepirodipine nicardipine...