Described herein are compositions and methods for treating or imaging Alzheimer's disease (AD). The compositions comprise a biotin moiety and a siRNA moiety, without the need for a targeting agent such as an antibody, avidin, or streptavidin. In certain embodiments, the compositions further comprise a diagnostic agent.

The invention provides a bird feed, comprising high dietary amounts of zinc bismethionine or high dietary amounts of zinc bismethionine and biotin. The invention further provides the use of the bird feed in a method for reducing and/or preventing the occurrence of footpad dermatitis in poultry. The invention additionally provides supplements and kits of parts for providing high dietary amounts of zinc bismethionine or of zinc and biotin to a poult.

The present invention refers to new classes of polymerisable monomers targeting biotin, a biotin derivative, a biotin analogue or a biotinylated molecule and related structures, as well as molecularly imprinted polymers obtainable by polymerisation of at least one of these monomers and at least one cross-linking monomer in the presence of a suitable template molecule. The obtained polymers may be used for separation of biotin and related small molecules, together with larger biotinylated molecul...

Provided herein are novel irreversible sialidase inhibitors. These compounds can be conjugated with a detectable tagging moiety such as azide-annexed biotin via CuAAC for isolation and identification of sialidases. The provided compounds and the corresponding detectable conjugates are useful for detecting sialidase-containing pathogens and imaging in situ sialidase activities under physiological conditions.

A polymerisable monomer (I) containing a recognition cleft for biotin comprises (i) an isophthalic acid derivative or a pyridine-2,6-dicarboxylic acid derivative and (ii) a vinyl-2-aminopyridine derivative for use as part of a molecularly imprinted polymer where X is C or N

The present invention relates to compositions and methods for prophylactic nutritional supplementation and therapeutic nutritional supplementation. Specifically the composition provides a nutritional supplement with a beneficial increased supplementation of vitamin D and the method involves administering to an individual a composition comprising carotenoids vitamin E vitamin D vitamin C thiamine riboflavin niacin folic acid pyridoxine biotin pantothenic acid cobalamin magnesium manganese zinc se...

To provide a bacterium-based microrobot which can be specifically targeted to cancer in vivo, the present invention provides a drug delivery system for cancer tissue, comprising a bacterium, and a microbead encapsulated with at least one drug, wherein biotin is bound to a surface of the bacterium and a surface of the microbead is coated with streptavidin.

The invention provides methods for treating multiple sclerosis by administering biotin. The invention also provides methods for treating sequalae after multiple sclerosis attacks by administering biotin.

The invention relates to the use of biotin for treating multiple sclerosis, in particular of the progressive forms and of the neurological sequelae.