FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to pharmaceutical industry, and represents a local skin composition which is an oil-in-water-in-oil emulsion containing a water phase with a dispersed lipophilic phase containing calcipotriol or monohydrate in the dissolved form

Use of vitamin D analogues selected from tacalcitol and (lS,3R,5E,7E,22E,24S)-24-cyclopropyl-9,10-secochola-5, 7,10(19),22-tetraen-1,3,24-triol (5,6-trans-calcipotriol) in combination with tyrosine kinase inhibitor imatinib in treatment of non-small cell lung cancer.

Disclosed is a process for the preparation of 24-alkyl analogs of cholecalcyferol of Formula 1 (see formula 1) having a (5E) or (5Z) configuration wherein X represents a hydrogen atom a hydroxy group or an OR1 group where R1 R2 and R3 may be the same or different and represent groups suitable for hydroxyl protection and R4 is a C1-6 alkyl chain or a C1-6 cykloalkyl group optionally substituted with C1-3 alkyl groups especially for calcipotriol. The invention also provides new non-racemic compoun...

PROBLEM TO BE SOLVED: To produce vitamin D analogues.

Calcipotriol monohydrate nanocrystals prepared by the process disclosed herein may be incorporated in a pharmaceutical composition for use in the prevention or treatment of dermal diseases and conditions.

The present invention relates to intermediates useful for the synthesis of calcipotriol or calcipotriol monohydrate, to methods of producing said intermediates, and to methods of stereoselectively reducing said intermediates.