The present invention relates to a method for treating a mammalian tumor/cancer using a polyene macrolide antibiotic selected from the group consisting of Filipin Candicidin Pimaricin Nystatin Etruscomycin and Candidin. In a preferred embodiment the method further comprises administration of a cholesterol lowering agent.

The present invention relates to a method for treating a mammalian tumor/cancer using a polyene macrolide antibiotic selected from the group consisting of Filipin Candicidin Pimaricin Nystatin Etruscomycin and Candidin. In a preferred embodiment the method further comprises administration of a cholesterol lowering agent.

PURPOSE: An antifungal agent containing tourmaline and a pharmaceutically acceptable ointment base as an active component is provided. It has an activity sufficient to be used as antifungal agent such that it can be used as an external application on infection of skin vagina hair or the like. CONSTITUTION: The antifungal agent comprises tourmaline selected from elbaite or dravite a pharmaceutically acceptable ointment base and a compound capable being used as an external agent. The content of to...

PURPOSE: An antifungal agent containing tourmaline and a pharmaceutically acceptable ointment base as an active component is provided. It has an activity sufficient to be used as antifungal agent such that it can be used as an external application on infection of skin vagina hair or the like. CONSTITUTION: The antifungal agent comprises tourmaline selected from elbaite or dravite a pharmaceutically acceptable ointment base and a compound capable being used as an external agent. The content of to...

New guanidine derivatives of polyene macrolides having at least one free amino group and at least one free carboxy group (e.g. nystatin pimaricin amphotericin B candicidin and trichomycin) are prepared by reacting the macrolide with a carbodiimide of the formula: RI-N=C=N-RII where RI and RII are independently alkyl substituted alkyl cycloalkyl aralkyl aryl or aroylalkyl. Esters and salts of the derivatives can also be formed. The new derivatives are water-soluble and can be used as anti-mycotic...

New guanidine derivatives of polyene macrolides having at least one free amino group and at least one free carboxy group (e.g. nystatin pimaricin amphotericin B candicidin and trichomycin) are prepared by reacting the macrolide with a carbodiimide of the formula RI-N=C=N-RII where RI and RII are independently alkyl substituted alkyl cycloalkyl aralkyl aryl or aroylalkyl. Esters and salts of the derivatives can also be formed. The new derivatives are water-soluble and can be used as anti-mycotic ...

New guanidine derivatives of polyene macrolides having at least one free amino group and at least one free carboxy group (e.g. nystatin pimaricin amphotericin B candicidin and trichomycin) are prepared by reacting the macrolide with a carbodiimide of the formula:EQU R.sup.1 --N.dbd.C.dbd.N--R.sup.2wherein R.sup.1 and R.sup.2 are independently alkyl substituted alkyl cycloalkyl aralkyl aryl or aroylalkyl. Esters and salts of the derivatives can also be formed. The new derivatives are water-solub...

New guanidine derivatives of polyene macrolides having at least one free amino group and at least one free carboxy group (e.g. nystatin pimaricin amphotericin B candicidin and trichomycin) are prepared by reacting the macrolide with a carbodiimide of the formula:where R1 and R" are independently alkyl substituted alkyl cycloalkyl aralkyl aryl or aroylalkyl. Esters and salts of the derivatives can also be formed. The new derivatives are water-soluble and can be used as anti-mycotic agents.

1472046 Fungicidal compositions F HOFFMANN-LA ROCHE & CO AG 19 Sept 1975 [20 Sept 1974] 38528/75 Heading A5B Fungicidal and fungistatic compositions comprise a) 5-fluoro-cytosine and b) nystatin candicidin or trichomycin in a free esterified or N-glycosylated form or a water-soluble physiologically tolerable salt thereof. The compositions are suitable for combating infections by fungi and yeasts of the skin muccous membranes and gastrointestinal and genital tracts e.g. vaginitis.

1472046 Fungicidal compositions F HOFFMANN-LA ROCHE & CO AG 19 Sept 1975 [20 Sept 1974] 38528/75 Heading A5B Fungicidal and fungistatic compositions comprise a) 5-fluoro-cytosine and b) nystatin candicidin or trichomycin in a free esterified or N-glycosylated form or a water-soluble physiologically tolerable salt thereof. The compositions are suitable for combating infections by fungi and yeasts of the skin muccous membranes and gastrointestinal and genital tracts e.g. vaginitis.