The present invention relates to an improved process for the preparation of Chlorothiazide and pharmaceutically acceptable salts thereof. The present invention relates to novel polymorphs of Chlorothiazide and Chlorothiazide salts, in particular Chlorothiazide sodium. The present invention further relates to pharmaceutical compositions comprising Chlorothiazide and Chlorothiazide salts, in particular Chlorothiazide sodium and process for preparation thereof.

The present invention relates to an improved process for the preparation of Chlorothiazide and pharmaceutically acceptable salts thereof. The present invention relates to novel polymorphs of Chlorothiazide and Chlorothiazide salts in particular Chlorothiazide sodium. The present invention further relates to pharmaceutical compositions comprising Chlorothiazide and Chlorothiazide salts in particular Chlorothiazide sodium and process for preparation thereof.

A fixed ratio low dose combination of benazepril and a thiazide diuretic is useful for treating hypertension particularly having about 4-6 mg of benazepril hydrochloride and about 5-7.5 mg of hydrochlorothiazide per dosage form. Suitable alternative thiazide derivatives are bendroflumethiazide chlorthalidone chlorothiazide hydroflumethiazide methylchlorothiazide polythiazide trichlormethiazide benzthiazide and cyclothiazide.

PURPOSE: To prepare a composition comprising bezenapril or its salt and a thiazide diuretic agent and capable of treating a lesser degree to a medium degree of hypertension in a lower dose than that when used alone. CONSTITUTION: This composition comprises bezenapril in about 4-6mg preferably about 5mg dose at a time or its pharmaceutically permissible salt and a thiazide diuretic agent in an amount of 80-120% preferably 100% based on 1/8 of the minimal antihyopertensive initial dose recommended...

PURPOSE: To prepare a composition comprising bezenapril or its salt and a thiazide diuretic agent and capable of treating a lesser degree to a medium degree of hypertension in a lower dose than that when used alone. CONSTITUTION: This composition comprises bezenapril in about 4-6mg preferably about 5mg dose at a time or its pharmaceutically permissible salt and a thiazide diuretic agent in an amount of 80-120% preferably 100% based on 1/8 of the minimal antihyopertensive initial dose recommended...

PURPOSE: To prepare a composition comprising bezenapril or its salt and a thiazide diuretic agent and capable of treating a lesser degree to a medium degree of hypertension in a lower dose than that when used alone. CONSTITUTION: This composition comprises bezenapril in about 4-6mg preferably about 5mg dose at a time or its pharmaceutically permissible salt and a thiazide diuretic agent in an amount of 80-120% preferably 100% based on 1/8 of the minimal antihyopertensive initial dose recommended...

The invention relates to the novel water soluble chlorothiazide in a complexed state which is derived from the reaction between and N-Vinyl actam polymer and chlorothiazide in alkaline media and to the process for the preparation of said complex.

The invention relates to the novel water soluble chlorothiazide-furosemide-poly(N-vinyl-2-pyrrolidone) complex which is derived from the reaction of these components in alkaline media and to the process for the preparation of said complex.

Dipeptides and amino acids of the formula A-E-G are disclosed wherein A is e.g. hydrogen or a- RbCO or RbSO2- where Ra and Rb are e.g. alkyl cycloalkyl or aryl;whereinR' is e.g. alkyl;n is 0 1;R2 is e.g. hydrogen or alkyl;R3 is OH NH2are e.g. alkyl;R4 is e.g. hydrogen or alkylR6 is H or methyl;R7 is e.g. hydrogen or alkyl;R8 is e.g. hydrogen methyl or cycloalkyl such that when R8 is cycloalkyl R6 and R7 are hydrogen;R9 is e.g. hydroxy.The compounds have enzyme inhibitor activity e.g. renin inhib...