Disclosed is a method of treatment or prevention of frailty in an elderly patient particularly having an age of 60 or older. The method provides the concomitant parenteral administration of a combination of an anabolic steroid and a vitamin D compound. A preferred combination comprises nandrolone decanoate and cholecalciferol (Vitamin D 3 ). The invention in a further preference provides a booster therapy to support frail elderly that have undergone hospitalization or surgery to retain independe...

We disclose treating hyperglycemia in a human with 25-hydroxyyitamin D3 (calcifediol). Blood glucose is reduced to a level which is closer to normal than baseline. Vitamin D3 (cholecalciferol) may optionally be used together with 25-hydroxy vitamin D3. Forms and dosages of a pharmaceutical composition, as well as processes for manufacturing medicaments, are also disclosed.

596057 Disclosed is a pharmaceutical composition comprising an anabolic steroid (such as oxymetholone oxandrolone nandrolone and esters thereof such as nandrolone decanoate) and a vitamin D compound (such as ergocalciferol cholecalciferol calcidiol calcitriol doxercalciferol or calcipotriene) in a carrier liquid wherein the composition is adapted for parenteral administration. Further disclosed is the use of an anabolic steroid and a vitamin D compound in the manufacture of a parenteral composit...

Disclosed is a process for the preparation of 24-alkyl analogs of cholecalcyferol of Formula 1 (see formula 1) having a (5E) or (5Z) configuration wherein X represents a hydrogen atom a hydroxy group or an OR1 group where R1 R2 and R3 may be the same or different and represent groups suitable for hydroxyl protection and R4 is a C1-6 alkyl chain or a C1-6 cykloalkyl group optionally substituted with C1-3 alkyl groups especially for calcipotriol. The invention also provides new non-racemic compoun...

The use of 25-OH D3 (calcifediol) to increase muscle strength, muscle function, or both is provided. Vitamin D3 (cholecalciferol) may optionally be used together with 25-OH D3. Forms and dosages of a pharmaceutical composition, as well as processes for manufacturing medicaments, are also disclosed.

The invention relates to a method and composition for the treatment of pain and / or inflammation, especially neuropathic pain and neurogenic inflammation. A topical or transdermal composition containing vitamin D, one or more saccharides or sugar alcohols and / or a salt or salts is disclosed which surprisingly act synergistically to relieve pain. In some embodiments, the vitamin D may comprise vitamin D3, for example cholecalciferol.

A method of reducing photodegradation of cholecalciferol when exposed to UV radiation in a composition containing cholecalciferol comprising combining with cholecalciferol a compound of formula (I) in an amount effective to quench excited state energy from cholecalciferol and transfer the excited state energy from cholecalciferol to the compound of formula (I) wherein one of R1 and R2 is a straight or branched chain C1-C30 alkoxy radical and the non-alkoxy R1 or R2 is hydrogen; and R3 is a strai...

Patent No. 595211 Disclosed is a drilling fluid comprising: a carrier fluid