A method for the preparation of Cinacalcet is disclosed comprising treating (R)-1-naphthyl ethylamine with an aromatic aldehyde to form (1R)-1-(2-naphthyl)-N-(aryl methylene)ethanamine derivative of Formula (IV), which is further treated with 1-(3-halopropyl)-3-(trifluoromethyl)benzene of Formula (V) to obtain an iminium salt of Formula (VI), followed by hydrolysis to obtain Cinacalcet free base.

A method for the preparation of Cinacalcet is disclosed comprising treating (R)-1-naphthyl ethylamine with an aromatic aldehyde to form (1R)-1-(2-naphthyl)-N-(aryl methylene)ethanamine derivative of Formula (IV) which is further treated with 1-(3-halopropyl)-3-(trifluoromethyl)benzene of Formula (V) to obtain an iminium salt of Formula (VI) followed by hydrolysis to obtain Cinacalcet free base.

The present patent application relates to a process for preparing cinacalcet or a pharmaceutically acceptable salt thereof, which comprises reacting 3-trifluoromethylbenzaldehyde having the following formula (II) with the phosphorus-comprising derivative having the following formula (III) in which R1 and R2, which may be identical or different, are each a (C1-C6)alkyl group. The present invention also relates to the phosphorus-comprising derivative having the formula (III), to the use thereof an...

A pharmaceutical composition comprises cinacalcet or its salt, solvate, derivative, hydrate, anhydrate, enantiomer, polymorph, prodrug or complex and at least one pharmaceutically acceptable polymer. A process for preparing a pharmaceutical composition comprising cinacalcet or its salt, solvate, derivative, hydrate, anhydrate, enantiomer, polymorph, prodrug or complex and at least one pharmaceutically acceptable polymer, comprises hot melt extrusion of the cinacalcet polymer blend to form extrud...

Disclosed are synthetic processes to produce phosphate salt of Cinacalcet unsaturated free base with a high degree of purity, and thereby producing Cinacalcet hydrochloride of very high purity by employing the above said intermediate along with an improved solvent system.

This invention relates to a process for the preparation of cinacalcet hydrochloride and its key intermediate 3-[3-(trifluoromethyl) phenyl]propionaldehyde, said process comprising reductive amination of 3-[3-(trifluoromethyl)phenyl]propionaldehyde and (R)-(1-napthylethylamine) in presence of activated sodium borohydride by an acid

The present invention is directed to methods and compositions for making and using a new polymorph of cinacalcet hydrochloride.

A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine of formula hydrochloride salt of formula (I) i.e. Cinacalcet.HCl and its intermediate of formula (IX)